A synthetic analog of histamine. It is an agonist of H1-receptors of inner ear vessels and an antagonist of H3-receptors of vestibular nuclei of CNS. By direct agonist effect on H1-receptors of the inner ear vessels, as well as indirectly through the effect on H3-receptors it improves microcirculation and capillary permeability, normalizes the endolymph pressure in the labyrinth and cochlea, increases blood flow in the basilar artery.
It has a pronounced central effect, being an inhibitor of H3-receptor nuclei of the vestibular nerve. It improves conduction in neurons of vestibular nuclei at brainstem level.
The clinical manifestation of the above properties is reduction of the frequency and intensity of dizziness, reduction of tinnitus, improvement of hearing if it is reduced.
absorption and distribution
Absorbed rapidly. Cmax is reached after 3 h. The binding to plasma proteins is low.
It is almost completely excreted in the urine as a metabolite (2-pyridylacetic acid) within 24 hours. T1/2 is 3-4 hours.
Meniere’s Disease, Vertigo, Brain Circulatory Disorder
- syndromes including dizziness and headache, tinnitus, progressive hearing loss, nausea and vomiting;
- treatment and prevention of vestibular vertigo of various origins;
- Meniere’s disease or syndrome.
betahistine dihydrochloride 24 mg;
Lactose (milk sugar);
Citric acid monohydrate;
Colloidal silicon dioxide (aerosil);
How to take, the dosage
Internal, with meals. 1/2-1 tablets 3 times a day.
Improvement is usually seen at the beginning of therapy.
Stable therapeutic effect occurs after two weeks of treatment and may increase over several months of treatment.
The treatment is long. The duration of the drug is chosen individually.
Patients with a history of gastric or duodenal ulcer disease, pheochromocytoma or bronchial asthma should be prescribed the drug under regular medical supervision.
Influence on driving and operating ability
Betahistine has no sedative effect and does not affect the ability to drive or engage in activities requiring rapid psychomotor reactions.
– lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
– childhood under 18 years of age (due to lack of data);
– pregnancy (for lack of data);
– lactation (for lack of data);
– hypersensitivity to any of the ingredients of the drug.
With cautiousness the drug should be prescribed in case of gastric or duodenal ulcer (in anamnesis), pheochromocytoma, bronchial asthma.
Gastrointestinal disorders, allergic reactions of the skin (skin rash, itching, urticaria), Quincke’s edema.
Symptoms: nausea, vomiting, seizures.
Treatment: Gastric lavage, administration of activated charcoal, symptomatic therapy.
Betaserk, Vestibo, Betahistine, Betahistine NW, Tagista, Vertran
|Conditions of storage|
In a light-protected place at a temperature not exceeding 25 °C.
Buy Betahistine-Vertex, tablets 24 mg 60 pcs with delivery to USA, UK, Europe and over 120 other countries.