Arutimol, eye drops 5 mg/ml 5 ml
€3.28 €2.98
Antiglaucoma drug of the group of non-selective beta-adrenoblockers.
Does not have intrinsic sympathomimetic and membrane stabilizing activity. When used topically as eye drops, it reduces both elevated and normal intraocular pressure by reducing the formation of intraocular fluid. It has no effect on accommodation, refraction and pupil size.
The action of the drug is seen 20 minutes after injection into the conjunctival sac. The maximum decrease of intraocular pressure (IOP) is reached within 1-2 hours and lasts for 24 hours.
Pharmacokinetics
Timolol maleate is slightly systemic absorbed when applied topically. After instillation of C max thymolol in the aqueous humor of the anterior chamber of the eye is reached after 1-2 hours.
In a small amount enters the systemic bloodstream by absorption through the vessels of the conjunctiva, nasal mucous membranes and the lacrimal tract. It is excreted by the kidneys as metabolites.
In infants and young children, C max timololol in plasma is greater than that in adult plasma.
Indications
Glaucoma, Elevated intraocular pressure
- Open angle glaucoma (in combination with miotics as an additional IOP lowering agent).
- Congenital glaucoma (when other therapeutic measures are not effective enough).
- Open angle glaucoma.
- Secondary glaucoma (including aphakic).
- Elevated intraocular pressure (ocular hypertension).
Active ingredient
Timolol
Composition
Active substance:
Timolol maleate – 6.83 mg (corresponds to timolol 5.0 mg).
Auxiliary substances:
Benzalkonium chloride solution (50%) corresponds to benzalkonium chloride,
povidone K 30,
Sodium dihydrophosphate dihydrate,
Sodium monohydrophosphate dodecahydrate,
Dihydrate dihydrate,
Water for injection.
.
How to take, the dosage
Arutimol eye drops are applied in 1-2 drops 1-2 times a day.
After IOP stabilization the dose may be reduced to 1 drop 1 time/day.
Interaction
- Timolol increases the effects of muscle relaxants.
- A BP decrease and slowing of heart rate may be potentiated by co-administration of Arutimol with calcium channel blockers, reserpine and beta-adrenoblockers.
- Simultaneous use with insulin or oral hypoglycemic agents may lead to hypoglycemia.
- Simultaneous use of Arutimol with eye drops containing adrenaline (epinephrine) may cause pupil dilation.
- IOP reduction is enhanced with concurrent use of eye drops containing adrenaline (epinephrine) and pilocarpine.
Special Instructions
Arutimol is prescribed with caution in patients with liver and kidney function abnormalities and diabetes mellitus.
For 30 minutes after injection, one should refrain from engaging in potentially hazardous activities requiring increased attention and rapid mental and motor reactions.
Persons should not wear soft contact lenses during treatment, and rigid lenses may be worn no earlier than 15 minutes after dosing.
When used together with beta-blockers, calcium channel blockers may cause excessive pressure reduction.
When using Arutimol at least once in 6 months one should control lacrimal function, corneal integrity and visual field.
Contraindications
- Hypersensitivity to thymolol.
- Allergic reactions with generalized skin rashes.
- Chronic obstructive airways disease (including bronchial asthma).
- Veep heart failure .
- Sinus bradycardia .
- AV blockade of degree II or III.
- Cardiogenic shock.
- Corneal dystrophy.
- Severe atrophic rhinitis.
The drug is used with caution in the following cases:
- In patients with thyrotoxicosis.
- In patients with chronic bronchitis and emphysema.
- Patients with diabetes receiving insulin or oral hypoglycemic agents (use of timolol may lead to hypoglycemia)
.
Side effects
- heart failure
- heart rhythm disorders
- pain, muscle weakness, decreased blood pressure
- headache, sleep disturbances, depression
- nausea, vomiting, diarrhea
- dermal allergic reactions
- nausea, vomiting, diarrhea
- dermal allergic reactions
- burning eyes
li>headache, sleep disturbances, depression
.
.
Overdose
Symptoms: bradycardia, bronchospasm, dizziness, headache, arrhythmia, nausea, vomiting.
Treatment: flush eyes with water or saline; symptomatic therapy if necessary.
Pregnancy use
Arutimol is contraindicated in pregnancy, lactation and early childhood.
Similarities
Arutimol, Okupres-E, Okumed, Timolol-Akos, Timolol Renewal, Timolol-SOLofarm
Weight | 0.014 kg |
---|---|
Shelf life | 36 months. After opening the bottle – 6 weeks. |
Conditions of storage | In a light-protected place at a temperature not exceeding 25 °C. |
Manufacturer | Dr. Gerhard Mann CFP, Germany |
Medication form | eye drops |
Brand | Dr. Gerhard Mann CFP |
Other forms…
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