Arutimol, eye drops 2.5mg/ml 5 ml

Antiglaucoma drug, nonselective blocker of β1- and β2-adrenoreceptors. It has no intrinsic sympathomimetic and membranostabilizing activity.

When used topically as eye drops, it reduces both normal and elevated intraocular pressure by reducing the formation of intraocular fluid. It has no effect on pupil size and accommodation.

The action of the drug is seen 20 min after injection into the conjunctival sac. The maximum decrease of intraocular pressure occurs after 1-2 hours and lasts for 24 hours.

Pharmacokinetics

Thymololol penetrates rapidly through the cornea when applied topically. After instillation of eye drops, Cmax of timolol in the aqueous humor of the anterior chamber of the eye is reached after 1-2 hours.

80% of timolol used in the form of eye drops enters the systemic bloodstream by absorption through the vessels of the conjunctiva, nasal mucosa and the lacrimal tract. Excretion of thymolol metabolites is carried out mainly by the kidneys.

In newborns and young children the Cmax in blood plasma is higher than in adult blood plasma.

Indications

Glaucoma, Elevated intraocular pressure

• Open angle glaucoma (in combination with miotics as an additional IOP lowering agent).
• Congenital glaucoma (when other therapeutic measures are not effective enough).
• Open angle glaucoma.
• Secondary glaucoma (including aphakic).
• Elevated intraocular pressure (ocular hypertension).

Active ingredient

Timolol

Composition

1 ml – timolol hydromaleate 3.42 mg, which corresponds to the content of timolol 2.5 mg

Auxiliary substances:

benzalkonium chloride solution (50%),

povidone K30,

sodium dihydrophosphate dihydrate,

sodium dodecahydrate monohydrophosphate,

sodium edetate dihydrate,

water d / i.

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How to take, the dosage

Apply Arutimol eye drops in 1-2 drops 1-2 times a day. After IOP stabilization it is possible to reduce the dose to 1 drop once a day.

Interaction

• Timolol increases the effects of muscle relaxants.
• A BP decrease and slowing of heart rate may be potentiated by co-administration of Arutimol with calcium channel blockers, reserpine and beta-adrenoblockers.
• Simultaneous use with insulin or oral hypoglycemic agents may lead to hypoglycemia.
• Simultaneous use of Arutimol with eye drops containing adrenaline (epinephrine) may cause pupil dilation.
• IOP reduction is enhanced with concurrent use of eye drops containing adrenaline (epinephrine) and pilocarpine.

Special Instructions

Arutimol is prescribed with caution in patients with liver and kidney function abnormalities and diabetes mellitus.

For 30 minutes after injection, one should refrain from engaging in potentially hazardous activities requiring increased attention and rapid mental and motor reactions.

Per treatment, soft contact lenses should not be used, and hard lenses may be worn up to 15 minutes after injection.

When used together with beta-blockers, calcium channel blockers may cause excessive pressure drop.

When using Arutimol at least once in 6 months one should control lacrimal function, corneal integrity and visual field.

Contraindications

• Hypersensitivity to thymolol.
• Allergic reactions with generalized skin rashes.
• Chronic obstructive airways disease (including bronchial asthma).
• Veep heart failure .
• Sinus bradycardia .
• AV blockade of degree II or III.
• Cardiogenic shock.
• Corneal dystrophy.
• Severe atrophic rhinitis.

The drug is used with caution in the following cases:

• In patients with thyrotoxicosis.
• In patients with chronic bronchitis and emphysema.
• Patients with diabetes receiving insulin or oral hypoglycemic agents (use of timolol may lead to hypoglycemia)

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Side effects

• heart failure
• heart rhythm disorders
• pain, muscle weakness, decreased blood pressure
• headache, sleep disturbances, depression
• nausea, vomiting, diarrhea
• dermal allergic reactions

li>headache, sleep disturbances, depression

• nausea, vomiting, diarrhea
• dermal allergic reactions
• burning eyes

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Overdose

Symptoms: dizziness, headache, arrhythmia, bradycardia, bronchospasm, nausea, vomiting.

Treatment: flush eyes with water or saline; symptomatic therapy if necessary.

Pregnancy use

Arutimol is contraindicated in pregnancy, lactation and early childhood.

Similarities

Arutimol, Okupres-E, Okumed, Timolol-Akos, Timolol Renewal, Timolol-SOLofarm