Anaprilin, tablets 10 mg 50 pcs

How to take, the dosage

Individual. When administered orally, the initial dose is 20 mg, the single dose is 40-80 mg; the maximum daily dose is 320 mg, the frequency of use is 2-3 times a day.

Interaction

During treatment with Anaprilin, intravenous administration of verapamil, diltiazem should be avoided.

The concomitant use of Anapriline with oral hypoglycemic agents or insulin may impair plasma glucose control and increase the risk of hyperglycemia.

Anapriline may also mask symptoms of onset of hypoglycemia.

Concomitant use of Anapriline and NSAIDs (particularly indomethacin) may decrease the antihypertensive effect of Anapriline, probably due to inhibition of prostaglandin synthesis in the kidneys and the consequent retention of sodium and fluid in the body.)

In concomitant use of Anaprilin and estrogen-containing drugs, fluid retention in the body may decrease the antihypertensive effect of Anaprilin.

The simultaneous use of Anaprilin with nitrates may increase the hypotensive effect.

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Special Instructions

After a long course of treatment the drug should be withdrawn gradually, under medical supervision.

The drug is prescribed with caution in patients with liver and/or kidney function disorders, diabetes mellitus.

In pheochromocytoma Anaprilin may be administered only after taking an alpha-adrenoblocker.

Halothane, isoflurane, methoxyflurane and trichloroethylene may increase the risk of myocardial dysfunction and hypotension when used with Anaprilin. Patients who have extensive surgical procedures planned have a higher risk of complications after abrupt withdrawal of Anaprilin than if treatment with beta-adrenoblockers is continued and the effects are compensated by proper anesthesia management.

Contraindications

• hypersensitivity;
• AV blockade II-III stage;
• sinoatrial block;
• sinus bradycardia (HR <55 beats.
• Sinus node weakness syndrome;
• arterial hypotension;
• heart failure II B-III stage.
• acute heart failure;
• acute myocardial infarction;
• vasomotor rhinitis;
• obliterative arterial disease (including Raynaud’s disease;
• metabolic acidosis;
• bronchial asthma;
• susceptibility to bronchospastic reactions;
• diabetes mellitus;
• pregnancy.

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Side effects

Possible: bradycardia, AV blockade, bronchospasm, heart failure, muscle weakness.

Rarely – headache, sleep disturbances, nightmares, asthenia, decreased ability to quick mental and motor reactions, agitation, depression, paresthesias and coldness of the extremities, nausea, diarrhea, constipation, skin allergic reactions, exacerbation of psoriasis, hypoglycemia, visual disturbances, keratoconjunctivitis.

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Overdose

Symptoms: marked bradycardia, dizziness, AV block, marked BP decrease, fainting, arrhythmia, ventricular extrasystole, CH, cyanosis of finger or palm nails, seizures, breathing difficulties, bronchospasm.

Treatment: gastric lavage, administration of activated charcoal, if AV conduction is impaired – 1-2 mg of atropine is administered intravenously, with low effectiveness, a temporary pacemaker is placed; if ventricular extrasystole – lidocaine (Class Ia drugs are not used); if BP decreases the patient should be in Trendelenburg position.

If there are no signs of pulmonary edema, plasma exchange solutions are administered by IV; if ineffective – epinephrine, dopamine, dobutamine; in CH – cardiac glycosides, diuretics, glucagon; in convulsions – IV diazepam; in bronchospasm – inhaled or parenteral beta-adreno stimulants.

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