Anaprilin, tablets 10 mg 50 pcs

Anapriline is antiarrhythmic, hypotensive, antianginal.

Pharmacodynamics

Decreases automatism of the sinus node, myocardial excitability, the occurrence of ectopic foci of excitation; Has membrane stabilizing effect, decreases HR, slows AV conduction, reduces myocardial contractility and myocardial oxygen demand.

It has a hypotensive effect, which stabilizes by the end of the 2nd week of treatment. Reduces the activity of the renin-angiotensin system. Increases the atherogenic properties of the blood.

Enhances uterine contractions (spontaneous and caused by means stimulating the myometrium), which helps to reduce bleeding during labor and in the postoperative period.

Enhances bronchial tone, in high doses causes a sedative effect.

Limits intraocular pressure by inhibiting the production of aqueous humor in the eye chamber, does not affect pupil size and accommodation.

Pharmacokinetics

It is rapidly absorbed when ingested and relatively quickly eliminated from the body. Cmax in blood plasma is reached after 1-1.5 h. Bioavailability after oral administration is 30% (effect of “first passage” through the liver, microsomal oxidation), increases after meals. T1/2 is 2-3 hours. Binding to blood plasma proteins is 90-95%. Penetrates through the placental barrier. Excretion by kidneys is 90%, in unchanged form – less than 1%.

Indications

Active ingredient

Composition

1 tablet contains:

The active ingredient:

10 mg propranololol;

Associates:

Milk sugar;

Talc;

How to take, the dosage

Individual. When administered orally, the initial dose is 20 mg, the single dose is 40-80 mg; the maximum daily dose is 320 mg, the frequency of use is 2-3 times a day.

Interaction

During treatment with Anaprilin, intravenous administration of verapamil, diltiazem should be avoided.

The concomitant use of Anapriline with oral hypoglycemic agents or insulin may impair plasma glucose control and increase the risk of hyperglycemia.

Anapriline may also mask symptoms of onset of hypoglycemia.

Concomitant use of Anapriline and NSAIDs (particularly indomethacin) may decrease the antihypertensive effect of Anapriline, probably due to inhibition of prostaglandin synthesis in the kidneys and the consequent retention of sodium and fluid in the body.)

In concomitant use of Anaprilin and estrogen-containing drugs, fluid retention in the body may decrease the antihypertensive effect of Anaprilin.

The simultaneous use of Anaprilin with nitrates may increase the hypotensive effect.

Special Instructions

After a long course of treatment the drug should be withdrawn gradually, under medical supervision.

The drug is prescribed with caution in patients with liver and/or kidney function disorders, diabetes mellitus.

In pheochromocytoma Anaprilin may be administered only after taking an alpha-adrenoblocker.

Halothane, isoflurane, methoxyflurane and trichloroethylene may increase the risk of myocardial dysfunction and hypotension when used with Anaprilin. Patients who have extensive surgical procedures planned have a higher risk of complications after abrupt withdrawal of Anaprilin than if treatment with beta-adrenoblockers is continued and the effects are compensated by proper anesthesia management.

Contraindications

Side effects

Possible: bradycardia, AV blockade, bronchospasm, heart failure, muscle weakness.

Rarely – headache, sleep disturbances, nightmares, asthenia, decreased ability to quick mental and motor reactions, agitation, depression, paresthesias and coldness of the extremities, nausea, diarrhea, constipation, skin allergic reactions, exacerbation of psoriasis, hypoglycemia, visual disturbances, keratoconjunctivitis.

Overdose

Symptoms: marked bradycardia, dizziness, AV block, marked BP decrease, fainting, arrhythmia, ventricular extrasystole, CH, cyanosis of finger or palm nails, seizures, breathing difficulties, bronchospasm.

Treatment: gastric lavage, administration of activated charcoal, if AV conduction is impaired – 1-2 mg of atropine is administered intravenously, with low effectiveness, a temporary pacemaker is placed; if ventricular extrasystole – lidocaine (Class Ia drugs are not used); if BP decreases the patient should be in Trendelenburg position.

If there are no signs of pulmonary edema, plasma exchange solutions are administered by IV; if ineffective – epinephrine, dopamine, dobutamine; in CH – cardiac glycosides, diuretics, glucagon; in convulsions – IV diazepam; in bronchospasm – inhaled or parenteral beta-adreno stimulants.