Akatinol Memantine, 20 mg 56 pcs.
€142.25 €123.29
Pharmacodynamics
As a non-competitive antagonist of N-methyl-D-aspartate (NMDA)-receptors it has modulatory effect on glutamatergic system. It regulates ion transport, blocks calcium channels, normalizes membrane potential, improves nerve impulse transmission. Improves cognitive processes, increases daily activity.
Pharmacokinetics
Akatinol Memantine is quickly and completely absorbed after oral administration. Maximum plasma concentration is reached within 2-6 hours. No cumulation of the drug is noted in normal renal function. Excretion is biphasic. Period of semiejection half-life is 4-9 hours in the first phase, and 40-65 hours in the second phase.
It is excreted in the urine.
Indications
Dementia of Alzheimer’s type, vascular dementia, mixed dementia of all degrees of severity.
Pharmacological effect
Pharmacodynamics
Being a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, it has a modulating effect on the glutamatergic system. Regulates ion transport, blocks calcium channels, normalizes membrane potential, improves the process of nerve impulse transmission. Improves cognitive processes, increases daily activity.
Pharmacokinetics
After oral administration, Akatinol Memantine is quickly and completely absorbed. The maximum concentration in blood plasma is achieved within 2-6 hours. With normal renal function, no accumulation of the drug was observed. Excretion occurs in two phases. The half-life is 4-9 hours in the first phase, 40-65 hours in the second phase.
Excreted in urine.
Special instructions
Patients with Alzheimer’s disease in the stages of moderate to severe dementia usually have impaired ability to drive vehicles and operate complex machinery.
In addition, memantine may cause a change in the reaction rate, so patients receiving treatment on an outpatient basis should take special care when driving or operating machinery.
Active ingredient
Memantine
Composition
Active ingredient:
memantine hydrochloride;
Excipients:
lactose;
MCC;
colloidal silicon dioxide;
talc;
magnesium stearate shell:
methacrylic acid copolymer;
sodium lauryl sulfate;
polysorbate 80;
triacetin;
simethicone emulsion;
talc.
Contraindications
individual hypersensitivity to the drug Akatinol Memantine;
severe renal dysfunction;
pregnancy;
breast-feeding;
children under 18 years of age (due to insufficient data).
With caution:
thyrotoxicosis;
epilepsy;
convulsions (including history);
myocardial infarction;
heart failure.
Side Effects
Adverse reactions are classified according to clinical manifestations (according to damage to certain organ systems) and frequency of occurrence: very often – ≥1/10; often – ≥1/100–
From the body as a whole – general adverse reactions Often Headache Rarely Fatigue Infections Rarely Fungal infections Mental disorders Often Drowsiness Rarely Confusion Rarely Hallucinations 1 Frequency not established Psychotic reactions 2 Disorders of the cardiovascular system Rarely Hypertension Rarely Venous thrombosis/thromboembolismGastrointestinal disordersFrequentConstipationRarelyNausea, vomitingFrequency not establishedPancreatitis2Central and peripheral nervous system disordersFrequentDizzinessRarelyGait disturbanceVery rarelyConvulsions
1Hallucinations have been observed mainly in patients with Alzheimer’s disease at the stage of severe dementia.
2 There are isolated reports of the occurrence of these adverse reactions when using the drug in clinical practice (data obtained after the drug went on sale).
Interaction
When used simultaneously with barbiturates, neuroleptics, and anticholinergics, the effect of the latter may be enhanced. When used together, it may change (increase or decrease) the effect of dantrolene or baclofen, so the doses of the drugs should be selected individually.
Overdose
Symptoms: increased severity of side effects.
Treatment: gastric lavage, taking activated carbon, symptomatic therapy.
Storage conditions
At a temperature not exceeding 25 °C
Shelf life
4 years
Manufacturer
Rottendorf Pharma GmbH, Germany
Shelf life | 4 years |
---|---|
Conditions of storage | At a temperature not exceeding 25 °C |
Manufacturer | Rottendorf Pharma GmbH, Germany |
Medication form | pills |
Brand | Rottendorf Pharma GmbH |
Other forms…
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