Akatinol Memantine, 20 mg 98 pcs
€228.87 €190.72
Pharmacodynamics
As a non-competitive antagonist of N-methyl-D-aspartate (NMDA)-receptors it has modulatory effect on glutamatergic system. It regulates ion transport, blocks calcium channels, normalizes membrane potential, improves nerve impulse transmission. Improves cognitive processes, increases daily activity.
Pharmacokinetics
Akatinol Memantine is quickly and completely absorbed after oral administration. Maximum plasma concentration is reached within 2-6 hours. No cumulation of the drug is noted in normal renal function. Excretion is biphasic. Period of semiejection half-life is 4-9 hours in the first phase, and 40-65 hours in the second phase.
It is excreted in the urine.
Indications
Concussion and other brain injuries, Stroke sequelae, Alzheimer’s disease, Acquired dementia, Alcoholism, Attention and memory disorders
Alzheimer’s type dementia, vascular dementia, mixed dementia of all degrees of severity.
Active ingredient
Memantine
Composition
Active substance:
Memantine gilrochloride 20 mg;
Ancillary substances:
lactose,
MCC,
colloidal silica,
Talc,
Magnesium stearate,
Shell:
methacrylic acid copolymer,
sodium lauryl sulfate,
talk.
How to take, the dosage
Akatinol Memantine is taken orally, with meals. Dosing regimen is set individually. It is recommended to start treatment with prescription of the lowest effective dose.
In adults with dementia during the 1st week of therapy – in a dose of 5 mg/day, the 2nd week – in a dose of 10 mg/day, the 3rd week – in a dose of 15-20 mg/day. If necessary, further weekly dose increase by 10 mg to reach a daily dose of 30 mg.
The optimal dose is reached gradually, increasing the dose each week.
Interaction
Concomitant use with barbiturates, neuroleptics, anticholinergic agents may increase the effect of the latter. Co-administration may change (increase or decrease) the effect of dantrolene or baclofen, so the doses of the drugs should be adjusted individually.
Special Instructions
The optimal dose is reached gradually, increasing the dose each week.
Contraindications
- individual hypersensitivity to the drug Akatinol Memantine;
- explicit renal dysfunction;
- pregnancy;
- breastfeeding;
- children under 18 years of age (due to insufficient data).
With caution:
- thyrotoxicosis;
- epilepsy;
- convulsions (including.
- myocardial infarction
- heart failure.
Side effects
Adverse reactions are classified according to their clinical manifestations (according to the involvement of certain organ systems) and their frequency of occurrence:
On the body as a whole – general adverse reactions | Often | Headache | ||
Rarely | Fatigue | |||
Infections | Rarely | Fungal infections | ||
Mental disorders | Often | Sleepiness | ||
Rarely | Confusion | |||
Rarely | Hallucinations1 | |||
Frequency not determined | Psychotic reactions2 | |||
Cardiovascular disorders | Rarely | Hypertension | ||
Rarely | Venous thrombosis/thromboembolism | |||
Gastrointestinal disorders | Often | Constipation | ||
Rarely | Nausea, vomiting | |||
Frequency not determined | Pancreatitis2 | |||
Disorders of the central and peripheral nervous system | Often | Dizziness | ||
Rarely | Impaired gait | |||
Very rarely | Seizures |
1Hallucinations have been observed primarily in patients with Alzheimer’s disease in the severe dementia stage.
2There have been anecdotal reports of these adverse reactions when the drug is used in clinical practice (data obtained after the drug was commercially available).
Overdose
Symptoms: increased severity of side effects.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.
Similarities
Noogeron, Maruksa, Memantal, Memaneirin, Memantine
Weight | 0.024 kg |
---|---|
Shelf life | 4 years |
Conditions of storage | At a temperature not exceeding 25 °C |
Manufacturer | Rottendorf Pharma GmbH, Germany |
Medication form | pills |
Brand | Rottendorf Pharma GmbH |
Other forms…
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