Akatinol Memantine, 10 mg 90 pcs
€130.02 €108.35
Akatinol Memantine is a myorelaxant of central action.
Being a non-competitive antagonist of N-methyl-D-aspartate (NMDA)-receptors it has modulating effect on glutamatergic system.
It regulates ion transport, blocks calcium channels, normalizes membrane potential, improves nerve impulse transmission, improves cognitive processes, memory and learning ability, and increases daily activity.
Indications
Dementia of Alzheimer’s type, vascular dementia, mixed dementia of all degrees of severity.
Decreased memory, concentration and learning ability.
Cerebral and spinal spastic syndrome, including due to traumatic brain injury, multiple sclerosis, stroke.
Pharmacological effect
Akatinol Memantine is a centrally acting muscle relaxant.
Being a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, it has a modulating effect on the glutamatergic system.
Regulates ion transport, blocks calcium channels, normalizes membrane potential, improves the process of nerve impulse transmission, improves cognitive processes, memory and learning ability, and increases daily activity.
Special instructions
Patients with Alzheimer’s disease in the stages of moderate to severe dementia usually have impaired ability to drive vehicles and operate complex machinery.
In addition, memantine may cause a change in the reaction rate, so patients receiving treatment on an outpatient basis should take special care when driving or operating machinery.
Active ingredient
Memantine
Composition
Film-coated tablets
1 table:
memantine hydrochloride 10 mg
excipients:
lactose;
MCC;
colloidal silicon dioxide;
talc;
Magnesium stearate shell:
methacrylic acid copolymer;
sodium lauryl sulfate;
polysorbate 80;
triacetin;
simethicone emulsion;
talc
Pregnancy
Contraindicated during pregnancy.
Breastfeeding should be stopped during treatment.
Contraindications
Individual hypersensitivity to the drug;
severe renal dysfunction;
pregnancy;
breast-feeding;
children under 18 years of age (due to insufficient data).
With caution:
thyrotoxicosis;
epilepsy;
convulsions (including history);
myocardial infarction;
heart failure.
Side Effects
Adverse reactions are classified according to clinical manifestations (according to damage to certain organ systems) and frequency of occurrence: very often – ≥1/10; often – ≥1/100–
From the body as a whole – common adverse reactions
Often
Headache
Rarely
Fatigue
Infections
Rarely
Fungal infections
Mental disorders
Often
Drowsiness
Rarely
Confusion
Rarely
Hallucinations
Frequency not set
Psychotic reactions
Cardiovascular disorders
Rarely Hypertension
Rare: Venous thrombosis/thromboembolism
Gastrointestinal disorders
Often Constipation
Rarely Nausea, vomiting
Frequency not set
Pancreatitis
Disorders of the central and peripheral nervous system
Often Dizziness
Rare Gait disturbance
Very rare Convulsions
1 Hallucinations have been observed primarily in patients with Alzheimer’s disease in the advanced stages of dementia.
2 There are isolated reports of the occurrence of these adverse reactions when using the drug in clinical practice (data obtained after the drug was marketed).
Interaction
When used simultaneously with L-dopa drugs, dopamine agonists, and anticholinergics, the effect of the latter may be enhanced.
When used simultaneously with barbiturates and neuroleptics, the effect of the latter may decrease.
When used together, it may change (increase or decrease) the effect of dantrolene or baclofen, so the doses of the drugs should be selected individually.
Concomitant use with amantadine, ketamine and dexamethophan should be avoided.
Plasma levels of cimetidine, procainamide, kinidine, kinin and nicotine may increase when taken simultaneously with memantine.
It is possible to reduce the level of hydrochlorothiazide when taken simultaneously with memantine.
Overdose
Symptoms: increased severity of side effects.
Treatment: gastric lavage, taking activated carbon, symptomatic therapy.
Storage conditions
At a temperature not exceeding 25 °C
Shelf life
4 years
Manufacturer
Rottendorf Pharma GmbH, Germany
Shelf life | 4 years |
---|---|
Conditions of storage | At a temperature not exceeding 25 °C |
Manufacturer | Rottendorf Pharma GmbH, Germany |
Medication form | pills |
Brand | Rottendorf Pharma GmbH |
Other forms…
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