Afrin, 0.05% spray 15 ml

An alpha-adrenergic stimulant for topical use. It has a vasoconstrictor effect.

Oxymetazoline causes vasoconstriction of the mucous membranes of the nose, sinuses and eustachian tube, which leads to reduction of their edema and release of nasal breathing in allergic and/or infectious inflammatory rhinitis (runny nose).

. Due to the presence of excipients in the composition of the medicine (microcrystalline cellulose and sodium carmellose and povidone-K29-32) Afrin® nasal spray does not leak from the nose and does not run down the throat because after the introduction into the nasal passages the spray becomes more viscous and is held on the nasal mucosa more effectively than the standard water solution.

According to clinical studies, the drug starts to work within 1 minute and the action lasts up to 12 hours.

Indications

Nasal breathing difficulties with colds, sinus inflammation, eustachitis, hay fever, allergic rhinitis, congestion and swelling of the conjunctiva.

Active ingredient

Composition

1 ml contains:

Active substance:

oxymetazoline hydrochloride 0.5 mg;

Auxiliary substances:

dinatrium edetate dihydrate – 300 µg,

sodium hydrophosphate – 975 µg,

sodium dihydrophosphate monohydrate – 5.525 mg,

povidone K29-32 – 30 mg,

benzalkonium chloride solution 17% – 1.471 mg,

macrogol 1450 – 50 mg,

benzyl alcohol – 2.5 mg,

microcrystalline cellulose and sodium carmellose (avicel RC-591) – 30 mg,

lemon flavoring – 1.5 mg,

purified water – q.s. to 1 ml.

How to take, the dosage

Intranasally.

Shake the bottle vigorously before each use.

Before using the nasal spray for the first time, you should “calibrate” it by pressing the head of the sprayer several times.

Adults and children over 6 years of age – 2-3 injections into each nasal passage with an interval of 10-12 hours. In adults, the frequency of use can be increased up to 3 times a day in adults. It is not recommended to exceed the indicated dose.

Interaction

The drug slows down absorption of local anesthetic drugs, prolongs the time of their action.

The concomitant use with other vasoconstrictor drugs increases the risk of side effects.

Concomitant use of MAO inhibitors (including a period of 14 days after their withdrawal), maprotiline and tricyclic antidepressants increases BP.

Special Instructions

In prolonged use (more than one week), nasal congestion symptoms may return.

Consult a doctor if it is necessary to continue treatment for more than 5 days.

Contact with the drug in the eyes should be avoided.

Impact on driving and operating machinery

The drug, when used correctly and in the recommended doses, has no effect on driving and operating machinery.br>

But if side effects such as dizziness occur, the patient should refrain from these activities.

Synopsis

Contraindications

Hypersensitivity, atrophic rhinitis, concomitant use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children under 6 years of age.

With caution

Coronary artery disease, arrhythmias, chronic heart failure, marked atherosclerosis, arterial hypertension, hyperthyroidism, thyrotoxicosis, diabetes mellitus, chronic renal failure, closed-angle glaucoma, prostatic hyperplasia with clinical symptoms, pregnancy, lactation period.

Side effects

Local reactions: transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing.

In long-term use – tachyphylaxis, reactive hyperemia and atrophy of the nasal mucosa.

Benzalkonium chloride, which is part of the drug, may cause localized skin reactions.

Systemic reactions: increased BP, increased anxiety, nausea, dizziness, headache, insomnia, palpitations, sleep disturbances.

Overdose

Symptoms: In significant overdose or accidental ingestion, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased BP, shortness of breath, psychiatric disorders, CNS depression (drowsiness, decreased body temperature, bradycardia, BP decrease, respiratory arrest and coma) are possible.

Treatment:symptomatic; in case of accidental ingestion – gastric lavage, activated charcoal. Vasopressor drugs are contraindicated.

Pregnancy use

The safety of the drug in pregnant and lactating women has not been established, so the drug should be prescribed to pregnant or lactating women only if the expected benefits to the mother exceed the potential risk to the fetus or infant.

Similarities