Acyclovir, tablets 200 mg 20 pcs

Pharmgroup:

antiviral drug.

Pharmic action:

The antiviral drug is a synthetic analog of thymidine nucleoside.

In infected cells containing viral thymidine kinase is phosphorylated and converted into acyclovir monophosphate. Under the influence of guanylate cyclase acyclovir monophosphate is converted into diphosphate and under the influence of several cellular enzymes into triphosphate. High selectivity and low toxicity for humans is caused by the absence of necessary enzyme for formation of acyclovir triphosphate in intact cells of macroorganism.

Aciclovir triphosphate, “being built” into the DNA synthesized by the virus, blocks virus multiplication. Specificity and very high selectivity of action are also due to its preferential accumulation in cells affected by the herpes virus.

Highly active against Herpes simplex viruses of types 1 and 2; viruses causing chicken pox and shingles (Varicella zoster); Epstein-Barr virus (types of viruses are listed in ascending order of MAC value of acyclovir).

It is moderately active against CMV.

In herpes it prevents formation of new rash elements, reduces the probability of cutaneous dissemination and visceral complications, accelerates crust formation, reduces pain in the acute phase of herpes zoster. It has an immunostimulatory effect.

Indications

Treatment and prevention of infections caused by Herpes simplex viruses types 1 and 2 and Varicella zoster:

Active ingredient

How to take, the dosage

Interaction

Concomitant use with probenecid increases the average half-life and decreases the clearance of acyclovir.

Concomitant use with nephrotoxic drugs increases the risk of renal dysfunction.

Special Instructions

When taking the drug, renal function (blood urea and plasma creatinine) should be monitored. When using the drug, it is necessary to ensure adequate intake of fluids.

Long-term or repeated treatment with acyclovir in patients with reduced immunity may lead to the emergence of virus strains that are insensitive to its action. Most acyclovir-insensitive virus strains isolated show a relative lack of viral thymidine kinase; strains with altered thymidine kinase or with altered DNA polymerase have been isolated.

In vitro action of acyclovir on isolated strains of Herpes simplex virus may cause the appearance of less sensitive strains. Acyclovir does not prevent sexual transmission of herpes, so during treatment it is necessary to refrain from sexual intercourse, even in the absence of clinical manifestations.

During treatment, caution should be exercised when driving vehicles and engaging in other potentially dangerous activities that require increased concentration and rapid psychomotor reactions.

Contraindications

Side effects

Overdose

Symptoms: agitation, coma, convulsions, lethargy.

Possible precipitation of acyclovir in the renal tubules if its concentration exceeds the renal tubule solubility (2.5 mg/ml).

Treatment: symptomatic.

Similarities