NSAIDS. It has analgesic and antipyretic, anti-inflammatory effects, and inhibits platelet aggregation. The mechanism of action is associated with inhibition of COX activity – the main enzyme of arachidonic acid metabolism, which is a precursor of prostaglandins that play a major role in the pathogenesis of inflammation, pain and fever.
Arthritis, Headache, Colds, Back pain, Arthrosis, Pain, Sore throat, Hangover, Migraine, Rheumatoid arthritis, Joint pain (arthralgia)
Rheumatism. Infectious allergic myocarditis. Rheumatoid arthritis. Prevention of thrombosis and embolism. Fever in infectious and inflammatory diseases.
1 tablet contains:
acetylsalicylic acid 500 mg.
How to take, the dosage
Individually, orally. For adults, the frequency of use is 2-6 times per day. The single dose varies from 40 mg to 1 g, the daily dose – from 150 mg to 8 g.
When concomitant use of calcium channel blockers, drugs that limit calcium intake or increase calcium excretion from the body, the risk of bleeding increases. When concomitant use, antacids containing magnesium and/or aluminum hydroxide slow down and reduce absorption of acetylsalicylic acid. When concomitant use with gold preparations, acetylsalicylic acid may induce liver damage.
Caution is used in patients with bronchial asthma, liver and kidney diseases, erosive-ulcerative lesions and gastrointestinal bleeding in the history, with increased bleeding or with simultaneous anticoagulation therapy, decompensated chronic heart failure. Acetylsalicylic acid even in small doses reduces excretion of uric acid from the body, which may cause an acute attack of gout in predisposed patients.
Gastrointestinal bleeding. Gastrointestinal erosive and ulcerative lesions in the acute phase. Hemorrhagic diathesis. “Aspirin triad”. History of urticaria, rhinitis, caused by taking acetylsalicylic acid and other NSAIDs. Hemophilia. Portal hypertension. Hypoprothrombinemia. Aortic dissecting aneurysm. Deficiency of glucose-6-phosphate dehydrogenase. Vitamin K deficiency. Reye’s syndrome. Renal and/or hepatic insufficiency. Hypersensitivity to acetylsalicylic acid and other salicylates. Childhood (under 15 years of age – the risk of Reye syndrome in children with hyperthermia against viral diseases). I and III trimesters of pregnancy. Period of lactation.
Digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea, rarely – the occurrence of erosive ulcers, gastrointestinal bleeding, liver dysfunction.
Symptoms (single dose of less than 150 mg/kg – acute poisoning is considered mild, 150-300 mg/kg – moderate, more than 300 mg/kg – severe): salicylitis syndrome (tinnitus, nausea, dizziness, vomiting, visual disturbances, general malaise, severe headache, fever – poor prognostic sign in adults). Severe poisoning – pulmonary hyperventilation of central genesis, drowsiness, metabolic acidosis, respiratory alkalosis, confused consciousness, collapse, anuria, bleeding, seizures.
In the second trimester of pregnancy a single dose is possible under strict indications.
Trombo ACC, Aspirin Cardio, Acetylsalicylic Acid, Upsarin Upsa, CardiASC, Trombopol, Aspirin Express
|Conditions of storage|
Store in a dry place at a temperature not exceeding 25oC. Keep out of reach of children.
Borisov Medical Preparations Plant, Belarus
Borisov Medical Preparations Plant
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