Thrombo ACS, 100 mg 100 pcs

How to take, the dosage

Orally, Tablets Thrombo ACS, without chewing, before eating, with a small amount of liquid.

Interaction

Simultaneous use of Thrombo ACC® increases the effect of the following drugs:
– thrombolytic and antiplatelet agents (ticlopidine);
– digoxin due to reduction of its renal excretion;
– Hypoglycemic agents (insulin and sulfonylurea derivatives) due to hypoglycemic properties of ASA at high doses and displacing sulfonylurea derivatives from protein binding;
– Valproic acid due to its displacement from protein binding.
– methotrexate due to decrease of renal clearance and displacement of it from protein binding;
– heparin and indirect anticoagulants due to disruption of platelet function and displacement of indirect anticoagulants from protein binding;

Additive effect is observed when concurrent administration of ASA with ethanol. ASA weakens the effect of uricosuric agents (benzbromaron) due to competitive tubular elimination of uric acid. Concomitant use of GCS increases excretion of salicylates and weakens their effects.

Special Instructions

When combining prescription with GCS, it should be remembered that during treatment the level of salicylates in blood is reduced, and after withdrawal of GCS an overdose of salicylates is possible.

The combination of ASA with ibuprofen is not recommended because the latter worsens the favorable effect of ASA on longevity. When ASA is combined with alcohol, there is an increased risk of gastrointestinal mucosa damage and prolonged bleeding time.

ASA can provoke bronchospasm as well as trigger bronchial asthma attacks and other hypersensitivity reactions. Risk factors include a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, as well as allergic reactions to other medications (itching, urticaria).

ASA may cause bleeding of varying severity during and after surgical interventions. Combination of ASA with anticoagulants, thrombolytics and antiplatelet agents is accompanied by an increased risk of bleeding.

ASA in low doses can provoke development of gout in predisposed persons with reduced excretion of uric acid. Combination of ASA with methotrexate is accompanied by an increased frequency of side effects from the hematopoietic system.

High doses of ASA have hypoglycemic effect that should be considered when prescribing it to patients with diabetes mellitus receiving hypoglycemic drugs.

Contraindications

– I and III trimesters of pregnancy;
– lactation (breastfeeding);
– childhood and adolescence under 18 years;
– gastrointestinal erosive and ulcerative lesions, gastrointestinal bleeding;
– “aspirin” asthma (bronchial asthma induced by taking salicylates and NSAIDs);
– Aspirin triad (a combination of bronchial asthma, recurrent polyposis of the nose and sinuses, and intolerance to acetylsalicylic acid);
– hemorrhagic diathesis;
– Metabolic syndrome. – Combined use with methotrexate at a dose of 15 mg or more per week;
– Hypersensitivity to acetylsalicylic acid, to excipients of the drug