🐾 Roncoleukin 250,000 IU for animals 1 ml ampoules, 3 pcs

Interleukin-2 is produced by a subpopulation of T-lymphocytes (T-helper I) in response to antigenic stimulation. The synthesized IL-2 affects T-lymphocytes, increasing their proliferation and subsequent synthesis of IL-2. The biological effects of IL-2 are mediated by its binding to specific receptors present on various cellular targets. IL-2 directly affects the growth, differentiation and activation of T- and B-lymphocytes, monocytes, macrophages, oligodendroglial cells, epidermal Langerhans cells, increases the synthesis of all immunoglobulin isotypes by plasma cells. IL-2 reduces the level of spontaneous apoptosis of helper T-lymphocytes, increases the production of interferons α, β, γ. The development of cytolytic activity of natural killer and cytotoxic T-lymphocytes depends on its presence. IL-2 causes formation of lymphokine-activated killer cells and activates tumor-infiltrating cells. Expansion of the spectrum of the effector cells lysing action causes elimination of a variety of pathogens, infected and malignized cells, which provides immune protection directed against tumor cell growth, as well as viral, bacterial and fungal infections.

Special instructions

Roncoleukin is compatible with most other drugs, but when using it, certain rules must be followed: it is undesirable to administer Roncoleukin with any other drugs and vaccines in the same syringe (except for bird vaccination); Do not administer Roncoleukin in solutions containing glucose, as the level of activity of the drug decreases. After using the immunomodulator Roncoleukin, animal products can be used for food purposes without restrictions.

Recommendations for use

Subcutaneously (s.c.): dissolve the contents of the ampoule in 2-5 ml of 0.9% sodium chloride solution or water for injection.

Intravenous (IV): transfer the contents of the ampoule with Roncoleukin to 100 – 400 ml of 0.9% sodium chloride for injection.

Intranasal: dissolve the contents of the ampoule in 4 ml of 0.9% sodium chloride solution or water for injection.

Instill into the nose at the following rate: for animals weighing up to five kilograms, use an ampoule of 100,000 IU, for animals weighing up to 20 kilograms, use an ampoule of 250,000 IU, for animals weighing over 20 kilograms, use an ampoule of 500,000 IU. Place two drops in each nostril at least 3-5 times a day.

Externally: dissolve the contents of the ampoule in 5-10 ml of 0.9% sodium chloride solution or water for injection and use as applications or surface irrigation.

Intercystial (intravesical): dissolve the contents of an ampoule of 100,000 – 250,000 IU in 5-50 ml (depending on the size of the animal) of 0.9% sodium chloride solution and inject through a catheter.

Orally: dissolve the contents of the ampoule in 2-10 ml of 0.9% sodium chloride solution or water for injection (depending on the size of the animal) and give the animal a drink.

Aerosol: dilute the contents of the ampoule in the required amount of 0.9% sodium chloride solution or water for injection and spray it on the installation or directly into the animal’s oral cavity.

When diluting Roncoleukin, you should not shake the ampoule vigorously to avoid foaming. The drug can be prescribed for therapeutic and prophylactic purposes, starting from newborn age.

Side Effects

Subcutaneous injection of Roncoleukin may be accompanied by a short-term, up to 1 minute, painful “burning” reaction. In order to reduce this effect, water for injection should be used to dilute the drug.

Contraindications

For cattle and horses with severe lesions of the conduction system and valvular apparatus of the heart, Roncoleukin is used with caution, in small doses. Myocardial infarction in cattle and horses is a contraindication for the use of Roncoleukin. Roncoleukin is not recommended for administration to horses shortly before or immediately after exercise, or in hot weather due to the hyperthermia effect. For malignant diseases of the blood and lymph, Roncoleukin should be used with caution. It is not recommended to use Roncoleukin simultaneously with local or systemic corticosteroid drugs.

Active ingredient

Interleukin 2

Manufacturer

Biotech NPK, Russia