🐾 Roncoleukin 500,000 IU for animals 1 ml ampoules, 3 pcs

Interleukin-2 is produced by a subpopulation of T-lymphocytes (T-helper I) in response to antigenic stimulation.

IL-2 affects T-lymphocytes, increasing their proliferation and subsequent synthesis of IL-2.

The mechanism of action of IL-2 is due to its binding to the specific receptors present on various cellular targets.

IL-2 specifically affects the growth, differentiation and activation of T- and B-lymphocytes, monocytes, macrophages, oligodendroglial cells, epidermal Langerhans cells.

The development of cytolytic activity of natural killers and cytotoxic T-lymphocytes depends on its presence. IL-2 causes the formation of lymphokine-activated killer cells and activates tumor-infiltrating cells.

Extension of the spectrum of effector cells lysing action causes elimination of a variety of pathogens, infected and malignant cells, which provides immune protection directed against tumor cell growth, viral, bacterial and fungal infections.

Indications

Prevention of mineral metabolism disorders:

– in animals during pregnancy (eclampsia)
– in growing and old animals
– in animals with breed predisposition to disorders of
mineral metabolism.

For correction of clinically diagnosable disorders of mineral metabolism:

– rickets
– osteomalacia
– osteodystrophy and others.

In treatment of fractures and bone fractures (as a part of the complex therapy).

Active ingredient

Interleukin 2

Composition

The active ingredient is recombinant human IL-2 (rIL-2).

Excipients: sodium dodecyl sulfate (solubilizer), D-mannitol (stabilizer), dithiothreitol (reducing agent), sodium carbonate ammonium, water for injection.

How to take, the dosage

Pets and fur animals Therapeutic use: viral, bacterial and fungal diseases – 2 – 5 injections intravenous (IV) or subcutaneous (p/k) at the rate of 10000-15000 ME/kg with 24-72 hours interval;

Oncological diseases – 5 IV or p/k injections at the rate of 15000-20000 ME/kg, repeated courses are given after a month.

Prophylactic use: to intensify the effectiveness of vaccines and reduce postvaccination complications – one injection of 5,000 IU/kg in a single dose or 24 – 48 hours before vaccination;

prevention of viral, bacterial and fungal diseases – 1 – 2 injections in a single dose, IV or orally at the rate of 5,000 IU/kg with an interval of 48 hours;

Prevention of complications during surgical interventions – before and/or after the surgery – 1 – 2 e/v or intravenous injections with 48-hour interval;

Stress relief after various manipulations, transportation etc.д. – over two days once at a rate of 5000 IU/kg; normalization of immunity of aged and weakened animals – 2 injections into the body by injection at a rate of 10000 IU/kg every 48 hours once in 3 to 6 months.

Horses Use: in respiratory diseases: pulmonary emphysema, bronchitis, pneumonia, – p/k, v/v, orally 2 – 3 injections at a dose of 1000 IU/kg at 24 – 72 hour intervals;

to prevent relapses of chronic respiratory diseases – monthly injections once a month in the dosage of 2000 IU/kg with the interval of 48 – 72 hours;

in case of skin diseases (photoexanthema, erythema multiforme): – 2 injections w/v, in a dose of 1000 IU/kg at 48-hour intervals in combination with local anti-inflammatory therapy, in dermatitis – w/v drip or p/c 3 – 5 injections at 48-hour intervals in the same dosage;

In patients with mineral metabolism disorders – twofold 1000 IU/kg by IV, p/c with 48-72 hour intervals, the repeated courses are carried out in a month and two months later;

In case of traumatic injuries, pododermatitis, burns and frostbite there are two to three injections (first injection by IV drip, subsequent ones by p/k) with the dose of 1000-2000 IU/kg with 48 hour interval;

In case of oncological diseases (melanosarcoma) – 3 – 5 injections at a rate of 1000-2000 ME/kg with an interval of 48-72 hours. The first injection is given by IV drops, the second one – subcutaneously, further 1 – 2 injections a month by IV;

For correction of foals’ immunity – 2 injections at a rate of 1000 – 2000 IU/kg by IV, p/k or orally; the first injection – on the 3rd-4th day, the second – on the 10th-14th day after birth;

to prevent dissemination of viral infections – 2 – 3 injections into the IV, p/u at a rate of 1000 IU/kg into all animals in contact with sick animals;

For prevention of transport stress – once in/v/v, orally at a rate of 1000 IU/kg 24 – 72 hours before loading of a horse; for old and weakened animals – once in/v/v, orally at a dose of 1000 IU/kg of body weight monthly by 2 – 3 injections.

During periods of high physical activity it is administered to increase the body’s reserve capacity – once a week by injections, i.v., orally, in a dose of 1000 ME/kg.

Immunorehabilitation after corticosteroid treatment and other immunosuppressants course – i.v., i.v., orally 1000 ME/kg 2 – 3 times with 48-72 hour intervals.

Cattle (Cattle) Administration:

to stimulate immunity in newborn calves – once p/k at 100,000 IU per calf; for prevention and treatment of viral, bacterial diseases – 1-3 p/k injections at a rate of 2000-3000 IU/kg with an interval of 48 hours;

to enhance the effectiveness of vaccination – once simultaneously with vaccination p/k at a rate of 1000-2000 IU/kg; in case of necrobacillosis – 2-3 injections into the cells by injection or intravenously (slowly) at the rate of 1000 IU/kg with 7-10 day intervals;

in case of chlamydia – three injections by injection at the rate of 1000 IU/kg with 7 day intervals;
For normalization (restoration) of the sexual cycle in cows with ovarian hypofunction manifested by prolonged anaphrodesis: 500,000 IU two times per animal with an interval of 36 hours.

Cattle The same indications and doses as in cattle.

Pigs To be used: For immunity stimulation of newborn piglets – once in / by oral doses of 3000 – 5000 IU/kg;

For prevention of viral, bacterial and fungal diseases – 1-2 injections once in / by oral doses of 2000 IU/kg with an interval of 48 hours;

To improve vaccination efficiency – once in parallel with immunization of young animals by oral injection at the rate of 2000-3000 IU/kg.

Poultry Farmers It is used for immunity stimulation of young birds and for improvement of vaccination efficiency and reduction of postvaccination complications. It is administered once daily by oral administering of 2000-3000 IU/kg.

Wild and exotic animals

In all exotic animal species 2 to 5 i/v or p/u injections with 24 – 72 hour intervals at the rate of Paired ungulates and brains – in the same doses as in cattle, unpaired ungulates – in the same doses as in horses, pinnipeds – 3000 – 5000 IU/kg, primates and reptiles – 10000 – 15000 IU/kg, birds – in the same doses as in poultry.

When treating exotic birds it is possible to use p/k, oral, intranasal administration method.

Pisces:

To sturgeon and their hybrids: In case of surgery – once before the surgery – once in a dose of 2000 IU/kg and after surgery – twice in a dose of 5000 IU/kg with 24-hour intervals, and also as an anti-stress therapy and to improve viability of fry:

once orally 7 days before stress in a dose of 6000 IU/kg, or three times in a dose of 2000 IU/kg at intervals of 48 hours for handling stresses, or as half-hour baths in a dose of 300000 IU/100L;

to salmonids and their hybrids for egg and larvae treatment when transferring to exogenous feeding – 15 minute baths at the rate of 250000 IU/100 L of water, once; and for juveniles up to 3 grams in weight as prevention of viral, bacterial and fungal diseases – orally together with food – 3 days in a row at the dose of 4000 IU/kg (3 courses with 10-14 days interval);

to trout producers in the post spawning period – 3 times irrigation of the food before feeding at the dose of 2000 IU/kg of ichthyomass with the interval of 5 days;

For prophylaxis and treatment of viral, bacterial and fungal diseases to aquarium fish – exposition in tanks with pure water in which Roncoleukin® is added at the rate of 50000 IU/10 L of water during 30-60 minutes.

Contraindications

A history of hypersensitivity to interleukin-2 or any component of the drug is contraindicated.

It is not recommended to administer to horses shortly before or immediately after physical activity; also in hot weather.

Horses with severe lesions of the cardiac conduction system and valve apparatus are administered with caution, in portions.