🐾 Onsior tablets 6 mg for cats from 2.5 kg to 12 kg Elanco, 6 pcs.

Onsior tablets refers to non-steroidal anti-inflammatory drugs.
Robenacoxib, a part of the drug, is a non-steroidal anti-inflammatory drug of coxib group, is a selective specific COX-2 inhibitor and has anti-inflammatory and analgesic effect. COX is present in two forms: COX-1, the constitutive form of the enzyme, performs protective functions, including in the gastrointestinal tract and kidneys; COX-2, the inducible form of the enzyme, is responsible for the production of mediators, including PGEs, that cause pain, inflammation and fever. When administered orally, robustacoxib is rapidly absorbed in the intestine, entering the systemic bloodstream and most organs and tissues; more than 99% of robustacoxib is bound to plasma proteins. Its maximum plasma concentration is observed after 0.5 hours, bioavailability is 49% in cats and 62% in dogs when using tablets with food and 84% without food. Robenacoxib is metabolized in the liver, excreted mainly with bile (about 70% in cats and about 65% in dogs) and partially with urine; half-life of dogs is about 1.2 hours, of cats – 1.7 hours. Onsior™ tablets according to the degree of effect on the body refers to moderately hazardous substances (Hazard Class 3 according to GOST 12.1.007).

Indications

Prescribed for puppies up to 18 months of age for prevention of mineral metabolism disorders and correction of O- and X-shaped posture of limbs. Adult dogs in the complex therapy of joint diseases of all kinds with involvement of bone tissue in the pathological process, as well as for accelerated healing and fracture healing. For dogs aged over 6 years for the prevention of osteomalacia and osteoporosis.

Active ingredient

Robenacoxib

Composition

Onsior tablets for cats as an active ingredient contains robenacoxib – 6 mg / tablet. As excipients preparation Onsior tablets contains: yeast, microcrystalline cellulose, flavoring identical to beef, powdered cellulose, povidone (K-30), crosspovidone, colloidal anhydrous silicon dioxide and magnesium stearate.

How to take, the dosage

Onsior tablets are administered to dogs and cats individually once a day in the doses shown in the table:

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It is recommended that the drug be given separately from the feed, but if necessary, the drug can be given along with the feed. The tablets should not be crushed or broken.
Onsior tablets are administered to cats during surgical interventions 30 minutes before insertion into anesthesia at the dose of 1-2.4 mg per 1 kg of body weight of the animal; the treatment may be continued for up to 2 days after surgery; in case of diseases of musculoskeletal system the drug is used for up to 6 days. The course of treatment shall be determined by the attending veterinarian.
As a rule, the duration of treatment is 7 days. If after 10 days the clinical improvement is not achieved, the drug is discontinued.
In case of overdose of the drug in animals with marked sensitivity to the drug components gastrointestinal disorders, liver or kidney failure may be observed.
There are no specific detoxification means, general measures for the elimination of the drug from the body are used.
No specific action of the drug at its first use and withdrawal.
Onsior tablets should not be used in pregnant and lactating animals, kittens under 4 months of age.
The recommended interval between the drug administration should be avoided as it may cause loss of therapeutic efficacy. In case of missed reintroduction the drug should be administered as soon as possible in the prescribed dose.

Special Instructions

Onsior tablets should not be used concomitantly with other nonsteroidal anti-inflammatory drugs and within 24 hours after their withdrawal, diuretics, as well as ACE inhibitors and other drugs with high degree of binding to serum proteins due to the possibility of mutual increase in toxic effect. The drug is not intended for use in productive animals.

Contraindications

Do not use Onsior tablets in animals in a state of dehydration, hypovolemia and hypotension, as well as in animals weighing less than 2.5 kg. If it is absolutely necessary to prescribe the drug to such animals, the treatment shall be carried out under constant supervision of a veterinarian. Individual hypersensitivity of the animal to the drug components is a contraindication to its use. The drug should not be used in animals with marked cardiac, renal and hepatic failure.

Side effects

When using Oncior tablets in accordance with these instructions side effects and complications in animals, as a rule, are not observed. Cats may have gastrointestinal disorders (vomiting, soft feces or diarrhea), these symptoms pass spontaneously and do not require the use of drugs. In case of individual hypersensitivity of the animal to the drug and appearance of allergic reactions, the drug shall be discontinued and the animal shall be prescribed antihistamines and symptomatic drugs.