🐾 Onsior tablets 5 mg for dogs from 2.5 kg to 5 kg Elanco, 28 pcs.

Onsior tablets refers to non-steroidal anti-inflammatory drugs.
Robenacoxib, a part of the drug, is a non-steroidal anti-inflammatory drug of coxib group, is a selective specific COX-2 inhibitor and has anti-inflammatory and analgesic effect. COX is present in two forms: COX-1, the constitutive form of the enzyme, performs protective functions, including in the gastrointestinal tract and kidneys; COX-2, the inducible form of the enzyme, is responsible for the production of mediators, including PGEs, that cause pain, inflammation and fever. When administered orally, robustacoxib is rapidly absorbed in the intestine, entering the systemic bloodstream and most organs and tissues; more than 99% of robustacoxib is bound to plasma proteins. Its maximum plasma concentration is observed after 0.5 hours, bioavailability is 49% in cats and 62% in dogs when using tablets with food and 84% without food. Robenacoxib is metabolized in the liver, excreted mainly with bile (about 70% in cats and about 65% in dogs) and partially with urine; half-life of dogs is about 1.2 hours, of cats – 1.7 hours. Onsior™ tablets according to the degree of impact on the body refers to the moderately hazardous substances (3rd class of hazard according to GOST 12.1.007).

Indications

It is administered to bitches for treatment of false puppiness and suppression of lactation for clinical indications (for example, early weaning of puppies).

Active ingredient

Robenacoxib

Composition

Oncior tablets contain robenacoxib as an active ingredient. Onsior tablets for dogs are available in 4 dosages containing robenacoxib: 5 mg/table, 10 mg/table, As excipients Onsior™ Tablets contains: yeast, microcrystalline cellulose, beef identical flavoring, powdered cellulose, povidone (K-30), crosspovidone, colloidal anhydrous silicon dioxide and magnesium stearate.

How to take, the dosage

Onsior tablets are administered to dogs and cats individually once a day in the doses shown in the table:

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It is recommended that the drug be given separately from the feed, but if necessary, the drug can be given along with the feed. Tablets should not be crushed or broken.
Onsior tablets are administered to dogs during surgical operations 30 minutes before induction of anesthesia in a dose of 1-2 mg per 1 kg of animal weight; the treatment may be continued for up to 2 days after surgery; in case of locomotor disorders the drug is used for up to 7 days. Onsior tablets for dogs are administered 30 minutes before or after feeding at a dose of 1-2 mg per 1 kg of animal weight. The course of treatment is determined by the attending veterinarian.
As a rule, the duration of treatment is 7 days. If after 10 days the clinical improvement is not achieved, the drug is discontinued.
In case of overdose of the drug in animals with marked sensitivity to the drug components gastrointestinal disorders, liver or kidney failure may be observed.
There are no specific detoxication means, general measures for the drug elimination from the body are used.
No specific action of the drug during the first use and withdrawal.
Onsior tablets should not be used in pregnant and lactating animals, puppies under 3 months of age.
The recommended interval between the drug administration should be avoided as it may cause reduction of therapeutic effectiveness. In case of missed reintroduction the drug should be administered as soon as possible in the prescribed dose.

Special Instructions

Onsior tablets should not be used simultaneously with other nonsteroidal anti-inflammatory drugs and within 24 hours after their withdrawal, diuretics, as well as ACE inhibitors and other drugs with high degree of binding to blood serum proteins due to the possibility of mutual increase of toxic effect. The drug is not intended for use in productive animals.
PERSONAL PROTECTION Measures
People with hypersensitivity to the drug components should avoid direct contact with Oncior tablets. In case of accidental contact of the drug with skin or mucous membranes, they should be immediately rinsed with plenty of water. Do not use empty containers from the drug for domestic purposes; they must be disposed of with household waste. When using Onsiora tablets follow general rules of personal hygiene and safety precautions provided for when working with drugs. It is forbidden to smoke, drink and eat during work. At the end of work you should thoroughly wash your face and hands with soap. In case of allergic reactions or in case of accidental ingestion of the drug you should immediately contact a medical facility (have the instructions for use of the drug or the label).

Contraindications

Do not use Onsior tablets in animals in a state of dehydration, hypovolemia and hypotension, as well as in animals weighing less than 2.5 kg. If it is absolutely necessary to prescribe the drug to such animals, the treatment shall be carried out under constant supervision of a veterinarian. Individual hypersensitivity of the animal to the drug components is a contraindication to its use. The drug should not be used in animals with marked cardiac, renal and hepatic failure.

Side effects

When using Oncior tablets according to these instructions side effects and complications in animals are usually not observed. In dogs gastrointestinal disorders (vomiting, soft feces or diarrhea) are possible, the above symptoms pass spontaneously and do not require the use of drugs. In case of individual hypersensitivity of the animal to the drug and appearance of allergic reactions, the drug shall be discontinued and the animal shall be prescribed antihistamines and symptomatic drugs.