🐾 Ivermec 1% solution, bottle 100 ml

Ivermec refers to antiparasitic drugs of systemic action of macrocyclic lactones class.

Ivermectin contained in the drug has a pronounced antiparasitic effect on larval and sexually mature phases of gastrointestinal nematodes, lungs and eyes, larvae of subcutaneous, nasopharyngeal, stomach gadflies, lice, blood suckers and sarcoptoid mites.

The mechanism of action of ivermectin is in its effect on chlorine ions current through membranes of nerve and muscle cells of the parasite. The main targets are glutamate-sensitive chlorine channels as well as gamma-aminobutyric acid receptors. Changing current of chlorine ions disrupts nerve impulses leading to paralysis and death of parasite.

After parenteral administration of the preparation ivermectin is quickly absorbed from the injection site and distributed in organs and tissues of animal providing parasiticidal action during 10-14 days. It is eliminated from animals with urine and bile, in lactating animals – also with milk.

According to the degree of exposure on the body according to GOST 12.1.007-76 Ivermectin is classified as “moderately hazardous” substances (3rd class of hazard). The active substance – ivermectin – is classified as “extremely hazardous” substances (1st class of hazard). The drug has no embryotoxic, teratogenic and mutagenic effects in the recommended doses, it is rapidly destroyed in the external environment. The drug is toxic to bees as well as to fish and other hydrobionts.

Indications

To kill fleas, lice, fleas and ixodid mites parasitizing on dogs, as well as to protect animals from their attacks, especially in the warm season (during the period of increased activity of parasites).

Active ingredient

Ivermectin

Composition

1 ml contains:

Active ingredients:

ivermectin – 10 mg;

tocopherol acetate (vitamin E) – 40 mg,

Excipients:

dimethylacetamide – 400 mg,

polyethylene glycol-660-hydrocystearate – 150 mg,

benzyl alcohol – 10 mg,

water for injection – up to 1 ml.

Directions for use

Ivermec is administered once intramuscularly observing the rules of asepsis: in pigs in the neck or inner surface of the thigh, in ruminants – in the croup or neck at the following doses:

– cattle, sheep, goats, deer and camels – 1.0 ml per 50 kg of animal weight (200 µg ivermectin per 1 kg of weight);

– pigs – 1.0 ml per 33 kg of animal weight (300 µg ivermectin per 1 kg of weight).

In severe cases of sarcoptoidosis the treatment is carried out twice with 8-10 days interval.

In case the volume of the injected solution is greater than 10 ml, it should be injected into the animal in several places.

Treatment of animals against nematode diseases is carried out in autumn before stabling and in spring before putting the animals out to pasture, against gadfly infestations – immediately after end of flying gadflies, against arachnoentomoses – by prescription.

Each series of the preparation is pre-tested on a small group (7-10 animals). In the absence of complications the whole livestock is treated within 3 days.

Ivermec should not be used simultaneously with drugs containing macrocyclic lactones due to possible mutual increase in toxic effect.

No specific features of the drug effect were revealed upon its first use and withdrawal.

Special Instructions

Slaughter for meat of ruminants, camels and pigs shall be allowed not earlier than 28 days after the last treatment with Ivermec. In case of forced slaughter of animals before the specified period, the meat may be used as feed for fur animals.

Milk of milking animals may be used for food no earlier than 28 days after the last drug administration. Milk obtained before the specified period may be used after boiling for feeding animals.

Contraindications

Contraindication to the use of the drug Ivermec is individual hypersensitivity of the animal to the components of the drug (including in the anamnesis). Do not use the drug in sick and emaciated animals with infectious diseases, pregnant females whose milk will be used for food purposes less than 28 days before the start of lactation.

Side effects

Some animals may have increased salivation, increased frequency of defecation and urination, ataxia. These symptoms usually disappear spontaneously without the use of therapeutic agents. In case of increased individual sensitivity of the animal to the drug components and appearance of allergic reactions the animal shall be prescribed antihistamines and means of symptomatic therapy.