🐾 Amoxicillin suspension 15% Livisto vial, 10 ml

Amoxicillin is a semi-synthetic antibiotic of the penicillin group. It has a broad spectrum of bactericidal action against Gram-positive (Actinomyces spp., Bacillus anthracis, Clostridium spp., Corynebacterium spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Staphylococcus spp, Streptococcus spp.) and Gram-negative microorganisms (Actinobacillus spp., Bordetella bronchiseptica, E. coli, Salmonella spp., Fusobacterium spp., Haemophilus spp., Moraxella spp., Pasteurella spp., Proteus mirabilis). The drug has no effect on penicillin-forming strains of microorganisms from the genera Klebsiella and Enterobacter, as well as Pseudomonas. Amoxicillin interferes with the synthesis of the bacterial cell membrane by inhibiting the enzymes of transpeptidase and carboxypeptidase and causing disruption of the osmotic balance, which leads to the death of the bacterium at the growth stage. The oily excipient included in the drug gradually releases micronized amoxicillin into the blood, thereby ensuring prolonged action of the antibiotic. When parenteral administration amoxicillin 15% is well absorbed into the blood from the injection site and rapidly distributed in the body, reaching the highest concentration in the muscle tissue, liver, kidney, gastrointestinal tract due to minor connection with plasma proteins (17 – 20%). Amoxicillin penetrates into the brain and bone fluid to a small extent, except in cases when the brain membrane is inflamed. Maximum plasma concentration is reached 1 – 2 hours after drug administration and remains at therapeutic levels for 48 hours. Amoxicillin is practically not metabolized. It is excreted mainly with urine, to a lesser extent with milk and bile.

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