Zyprexa, 5 mg 28 pcs

Zyprexa is an antipsychotic.

As a ligand of serotonin (2A/2C, 3, 6), dopamine (D₁-D₅), m-choline (m₁-m₅), histamine H₁– and alpha₁-adrenoreceptors, and selectively affects the limbic system.

Pharmacokinetics

It is well absorbed, C_max in plasma in 5-8 h. Metabolized in the liver (by conjugation and oxidative pathways) to inactive metabolites. The main metabolite – 10-N-glucuronide – does not pass through the BBB. Mean T_1/2 varies (depending on age and sex) between 21-54 h.

Indications

The acute form of schizophrenia and other psychoses, accompanied by marked positive (delirium, hallucinations, thought disorders, hostility, suspiciousness) and/or negative (blunted affect, emotional and social detachment, poverty of speech activity) symptoms.

Secondary affective symptoms on the background of schizophrenia and related disorders.

Active ingredient

Composition

Active ingredient:

olanzapine 5 mg

How to take, the dosage

Ingestion, regardless of meals. The initial dose is from 10 mg/day, once.

Thereafter, the daily dose may vary from 5 to 20 mg/day, depending on the clinical condition.

Interaction

It reduces the effects of levodopa and dopamine agonists.

Active charcoal reduces bioavailability by 50-60% when taken orally.

Smoking and carbamazepine accelerate metabolism. No obvious interaction with antacids, cimetidine, imipramine, warfarin, diazepam, lithium, theophylline, biperidine has been found.

Contraindications

Hypersensitivity

Side effects

Frequent – somnolence, weight gain; rare – dizziness, dry mouth, constipation, peripheral edema, orthostatic hypotension, akathisia, dystonia, eosinophilia (asymptomatic), slight and temporary increase in prolactin levels (gynecomastia, lactorrhea), liver transaminase activity.

Overdose

Symptoms: nausea, confused speech, drowsiness. Midriasis, respiratory depression, hypotonia, extrapyramidal disorders have been reported in animal experiments.

Treatment: there is no specific antidote. Treatment is symptomatic, with mandatory use of activated charcoal, ensuring good ventilation and oxygen saturation; in case of collapse – intravenous administration of noradrenaline (but not adrenomimetics with beta-stimulating activity – adrenaline, dopamine, etc.).

Pregnancy use

Zyprexa is contraindicated in pregnancy, breastfeeding, and children under 18 years of age.

Similarities