Vitamin E (alpha-tocopherol acetate), capsules 100 mg 10 pcs

ATC code: A11NA03.

Pharmacological action

Vitamin E is an antioxidant. Protects cell membranes of body tissues from oxidative changes, stimulates the synthesis of heme and heme-containing enzymes – hemoglobin, myoglobin, cytochromes, catalase, peroxidase. Inhibits the oxidation of unsaturated fatty acids and selenium.

Inhibits the synthesis of cholesterol. Prevents hemolysis of red blood cells, increased capillary permeability and fragility, disruption of the function of the seminal tubules and testicles, the placenta, and normalizes reproductive function.

Pharmacokinetics

Absorption from the duodenum (requires the presence of bile salts, fats, normal function of the pancreas) – 50 – 80%. It binds with beta-lipoproteins of the blood. Transport is complicated in protein metabolism disorders. ÒCmax – 4 hours. It is deposited in all organs and tissues, especially in adipose tissue.

It penetrates through the placenta in insufficient quantities: 20-30% of concentration in mother’s blood penetrates into fetal blood. Penetrates into breast milk. Metabolized in the liver to derivatives with quinone structure (some of them have vitamin activity). It is excreted with bile – more than 90% (some amount is re-absorbed and subjected to enterohepatic circulation), by the kidneys – 6% (as glucuronides of tocopherolic acid and its gamma – lactone).

Indications

Hypovitaminosis E.

In the treatment of: muscular dystrophies; dermatomyositis; atherosclerosis, myocardiodystrophies; menstrual disorders; threat of termination of pregnancy, disorders of genital glands in men; dermatosis, psoriasis.

Composition

1 caps. Contains:

Active ingredients:

Vitamin E (tocopherol acetate) 100 mg,

Assistants:

Sunflower oil – 100 mg.

Capsule shell composition:

gelatin – 44.73 mg, glycerol – 14.67 mg, methyl parahydroxybenzoate – 0.29 mg, azorubin dye – 0.31 mg.

How to take, the dosage

100-300 mg daily orally, if necessary up to 1 g daily.

In diseases of the neuromuscular system 100 mg daily for 1-2 months. The second course is carried out every 2-3 months.

In case of spermatogenesis and potency disorders – 100-300 mg daily in combination with hormonal therapy for a month.

In case of threatening abortion – 100 mg daily for 7-14 days, in case of habitual abortion and inferior fetal development – 100 mg daily in the first 2-3 months of pregnancy daily or every other day.

In peripheral vascular diseases, myocardiodystrophy, atherosclerosis it is taken 100 mg per day (with vitamin A) for 20-40 days, in 3-6 months the therapy course may be repeated.

In dermatology it is taken 100 mg per day for 20-40 days.

Interaction

Vitamin E enhances the effect of glucocorticosteroid drugs, nonsteroidal anti-inflammatory drugs, cardiac glycosides.

Reduces the efficiency and toxicity of vitamins A and D. Increases the effectiveness of antiepileptic drugs in patients with epilepsy.

It is not recommended to take other multivitamin complexes containing vitamin E, to avoid overdose.

Simultaneous administration of high doses of vitamin E with iron, vitamin K or anticoagulants (agents that prevent blood clotting) increases the time of blood clotting.

Contraindications

Increased individual sensitivity to the components of the drug, acute myocardial infarction, childhood.

With caution: hypoprothrombinemia, severe cardiosclerosis, myocardial infarction, increased risk of thromboembolism.

Overdose

Symptoms: when taking vitamin E for a long period at doses of 400-800 mg / day: – blurred vision, dizziness, headache, nausea, fatigue, diarrhea, gastralgia, asthenia.

When administered over 800 mg/day for a long period – increased risk of bleeding in patients with hypovitaminosis K, impaired thyroid hormone metabolism, sexual dysfunction, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hyperbilirubinemia, renal failure, retinal hemorrhage, hemorrhagic insult, ascites.

Treatment: symptomatic. Withdrawal of the drug, prescription of glucocorticosteroid drugs.