Vitamin E, 400 mg capsules 30 pcs

Vitamin E is an antioxidant, participates in cell proliferation, tissue metabolism, prevents hemolysis of red blood cells, prevents increased permeability and capillary fragility.

The drug prevents the development of atherosclerosis and degenerative-dystrophic changes in the heart muscle and skeletal muscle, improves nutrition and myocardial contractility, reduces myocardial oxygen consumption. Inhibits free radical reactions, prevents the formation of peroxides that damage cell and subcellular membranes. Stimulates the synthesis of heme and heme-containing enzymes – hemoglobin, myoglobin, cytochromes, catalase, peroxidase.

Participates in the metabolism of nucleic acids and prostaglandins, in the cell respiratory cycle and in the synthesis of arachidonic acid.

It improves tissue respiration, stimulates protein synthesis (collagen, enzyme, structural and contractile proteins of skeletal and smooth muscles, myocardium), protects vitamin A from oxidation, inhibits cholesterol synthesis, helps normalize blood plasma lipid levels. Inhibits the oxidation of unsaturated fatty acids and selenium (a component of the microsomal electron transport system).

Activates phagocytosis and is used to maintain normal erythrocyte resistance. In high doses it prevents platelet aggregation. It has a pronounced positive effect on the human reproductive system.

With insufficiency of vitamin E there is a decrease in the concentration of proteins in the blood serum and the content of nucleic acids in the liver and testes.

Human insufficiency of vitamin E can be caused by dietary habits (for example, lack of vegetable fats in food) or by various diseases, such as liver, pancreas, etc.

Pharmacokinetics

From the gastrointestinal tract approximately 50% of the administered dose is absorbed, the maximum level in the blood is created after 4 hours. Bile acids, fats, normal pancreatic function are required for absorption. During absorption it forms a complex with lipoproteins, which are intracellular carriers of vitamin E.

It enters mainly into the lymph, then into the general bloodstream, where it binds mainly with alpha1 and beta-lipo-proteins, partially with serum albumin. When protein metabolism is impaired, transport is hindered. It is deposited in all organs and tissues, especially in adipose tissue. It is metabolized in the liver to derivatives with quinone structure (some of them have vitamin activity). It is excreted in bile (more than 90%) and urine (about 6%) unchanged and as metabolites.

It penetrates through the placenta in insufficient quantities: 20 – 30% of the concentration in the blood of the mother enters the fetus’s blood. It penetrates into breast milk.

Indications

For treatment of vitamin E hypovitaminosis; states of recuperation after diseases; asthenic conditions (including the elderly).

In the complex therapy of amyotrophic lateral sclerosis, degenerative and proliferative changes of joints and ligament apparatus (including spine). In women – in hormonal treatment of menstrual cycle disorders, in deteriorating conditions of fetal intrauterine development, in peripheral vascular lesions (endarteritis, Raynaud’s disease), In necrotizing myopathy, abetalipoproteinemia, gastrectomy, chronic cholestasis, liver cirrhosis, biliary atresia, obstructive jaundice, celiac disease, tropical sprue, Crohn’s disease, malabsorption, menopause, nicotine addiction, drug addiction.

Composition

How to take, the dosage

Capsules 400 mg: 1 capsule daily for adults.

The duration of treatment of hypovitaminosis E is individual and depends on the severity of the condition. If necessary, the dose can be increased up to 1 g per day.

It is not recommended to use with other multivitamin preparations for a long time because an overdose of fat-soluble vitamin E is possible.

Interaction

It increases the effectiveness of anticonvulsants in patients with epilepsy who are found to have increased levels of lipid peroxidation products in the blood.

It enhances the effect of steroid and non-steroidal anti-inflammatory drugs, antioxidants. Increases the effectiveness and reduces the toxicity of cardiac glycosides and vitamins A and D. Administration of vitamin E in high doses may cause vitamin A deficiency in the body.

The simultaneous use of vitamin E in doses greater than 400 mg/day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding.

Colestyramine, colestipol, mineral oils decrease absorption of alpha-tocopheryl acetate.

High doses of iron increase oxidative processes in the body, which increases the need for vitamin E.

Concomitant use of alpha-tocopheryl acetate with cyclosporine increases the absorption of the latter.

Special Instructions

The dosing regimen should be strictly adhered to.

A diet high in selenium and sulfur-containing amino acids reduces the need for vitamin E.

In congenital bullous epidermolysis, white hair may begin to grow in areas affected by allopecia.

If prolonged use of the drug and/or if repeated courses of therapy are necessary, it is recommended that clotting parameters and blood cholesterol levels be monitored periodically.

Cautions

With caution should be used in severe cardiosclerosis, after myocardial infarction, with an increased risk of thromboembolism, and with hypoprothrombinemia (with vitamin K deficiency – may increase with a dose of more than 400 mg of vitamin E).

Contraindications

Overdose

Symptoms: when taken for a prolonged period at doses of 400-800 mg/day – blurred vision, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia; when taken more than 800 mg/d for a long period – increased risk of bleeding in patients with hypovitaminosis K, impaired thyroid hormone metabolism, sexual dysfunction, thrombophlebitis, thromboembolism, necrotizing colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, retinal hemorrhages, hemorrhagic stroke, ascites, hemolysis.

Treatment: drug withdrawal; prescribe glucocorticoids that accelerate vitamin E metabolism in the liver; prescribe Vicasol to reduce the risk of hemorrhages.

Pregnancy use

Vitamin E is used during pregnancy and while breastfeeding only with a doctor’s prescription.