Vitamin C, effervescent tablets 250 mg 20 pcs
€7.63 €6.36
Pharmacological properties
Ascorbic acid is a vitamin, has metabolic action,
It is not formed in the human body, but comes only with food.
In an unbalanced and incomplete diet, a person is deficient in ascorbic acid.
Participates in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration. Increases resistance to infections, reduces vascular permeability,
reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.
Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine,
Fe, carbohydrate utilization, synthesis of lipids, proteins, carnitine, immune reactions, serotonin hydroxylation, increases absorption of non-hemin Fe.
Has anti-aggregant and pronounced antioxidant properties.
Regulates H+ transport in many biochemical reactions, improves glucose utilization in the tricarboxylic acid cycle,
Participates in the formation of tetrahydrofolic acid and tissue regeneration, synthesis of steroid hormones, collagen, procollagen.
Maintains colloidal state of intercellular substance and normal capillary permeability (inhibits hyaluronidase).
Activates proteolytic enzymes, participates in the metabolism of aromatic amino acids, pigments and cholesterol,
promotes the accumulation of glycogen in the liver. By activating respiratory enzymes in the liver it increases its detoxifying and protein-forming functions and increases prothrombin synthesis.
It improves bile secretion, restores external secretory function of the pancreas and thyroid.
Regulates immunological reactions (activates the synthesis of antibodies, C3 component of complement, interferon),
Phagocytosis promotes, increases resistance to infection.
Inhibits release and accelerates degradation of histamine, inhibits formation of Pg and other mediators of inflammation and allergic reactions.
In low doses (150-250 mg/day orally) it improves complexing function of deferoxamine in chronic intoxication with Fe, which leads to increased excretion of Fe.
Pharmacokinetics
Absorbed in the gastrointestinal tract (GIT) (mainly in the jejunum).
With increasing dose up to 200 mg absorbed up to 140 mg (70%); with further increasing dose absorption decreases (50-20%).
The binding to plasma proteins is 25%. Gastrointestinal diseases (gastric and 12 duodenal ulcer, constipation or diarrhea, helminth infestation, giardiasis), consumption of fresh fruit and vegetable juices and alkaline drinking reduce ascorbate absorption in intestine.
The concentration of ascorbic acid in plasma is normally about 10-20 mcg/ml, the body stores about 1.5 g when taking the daily recommended doses and 2.5 g when taking 200 mg/day,time to maximum concentration after oral administration – 4 hours.
Easily penetrates into leukocytes, platelets, and then into all tissues;
The highest concentration is reached in glandular organs, leukocytes, liver and eye lens;
Deposited in the posterior pituitary gland lobe, adrenal cortex, ocular epithelium, interstitial cells of seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates through the placenta.
The concentration of ascorbic acid in white blood cells and platelets is higher than in red blood cells and plasma.
In deficiency states, the concentration in leukocytes decreases later and more slowly and is considered a better criterion for assessing deficiency than plasma concentrations.
Metabolized primarily in the liver to deoxyascorbic acid and then to oxalic and diketogulonic acids.
Excreted by the kidneys, through the intestines, with sweat, breast milk as unchanged ascorbate and metabolites.
In high doses the excretion rate increases dramatically.
Smoking and use of ethanol accelerate the breakdown of ascorbic acid (conversion to inactive metabolites), dramatically reducing the body’s reserves.
Excreted by hemodialysis.
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Form of release
Effervescent tablets.
Shelf life | 2 years. Do not use after the expiration date printed on the package. |
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Conditions of storage | Store in a dry, light-protected place at 15 to 25 oC. Keep out of reach of children! |
Manufacturer | Chemopharm A.D., Serbia |
Medication form | pills |
Brand | Chemopharm A.D. |
Other forms…
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