Vibrocil, spray 15 ml

Pharmacotherapeutic group: Antinoconstrictive drug

ATX code. R01AB01

Pharmacological properties: Vibrocil is a combination drug containing phenylephrine and dimethindene.

Phenylephrine is a sympathomimetic agent, when used topically it has a moderate vasoconstrictor effect (due to stimulation of alpha1-adrenoreceptors located in the venous vessels of the nasal mucosa), it eliminates swelling of the nasal mucosa and its accessory sinuses.

Dimetinden is an anti-allergic agent – an antagonist of histamine H1-receptors; it does not reduce activity of the nasal mucosal epithelium.

Pharmacokinetics. Vibrocil is intended for topical use and its activity is independent of the concentration of active substances in blood plasma.

Indications

Acute rhinitis (including runny nose due to colds); allergic rhinitis (including hay fever); vasomotor rhinitis; chronic rhinitis; acute and chronic sinusitis; acute otitis media (as an auxiliary treatment method). Preparation for surgical interventions in the nasal area and elimination of swelling of the nasal mucosa and paranasal sinuses after surgical interventions in this area.

Pharmacological effect

Pharmacotherapeutic group:
Anticongestant

ATX code. R01AB01

Pharmacological properties:
Vibrocil is a combination drug containing phenylephrine and dimethindene.

Phenylephrine is a sympathomimetic agent; when applied topically, it has a moderate vasoconstrictor effect (due to stimulation of alpha1-adrenergic receptors located in the venous vessels of the nasal mucosa), eliminates swelling of the nasal mucosa and its paranasal sinuses.

Dimetindene is an antiallergic drug – an antagonist of histamine H1 receptors; does not reduce the activity of the ciliated epithelium of the nasal mucosa.

Pharmacokinetics. Vibrocil is intended for topical use, and its activity does not depend on the concentration of active substances in the blood plasma.

Special instructions

Vibrocil in gel form is especially indicated in case of dry nasal mucosa, in the presence of crusts, in the consequences of nasal trauma, as well as to prevent nasal congestion at night.

Vibrocil should not be used for more than 1 week without consulting a doctor. Long-term (more than 2 weeks) or excessive use of the drug can cause tachyphylaxis, and the “ricochet” effect (rhinitis medicamentosa), lead to the development of a systemic vasoconstrictor effect.

Do not exceed the recommended doses of Vibrocil! Otherwise, manifestations of the systemic effect of the drug may develop.

For children under 6 years of age, only nasal drops are used.

Vibrocil does not have a sedative effect (does not affect the speed of psychomotor reactions).

Can be used during lactation.

Phenylephrine (as well as other vasoconstrictors) is contraindicated in patients currently receiving MAO inhibitors or who have received them within the previous 2 weeks.

The drug should not be prescribed simultaneously with tricyclic antidepressants or beta-blockers.

Active ingredient

Dimetindene, Phenylephrine

Composition

Active ingredients:

Phenylephrine 2.5 mg;

Dimetindene maleate 250 mcg.

Excipients:

Benzalkonium chloride 50% solution (in terms of benzalkonium chloride) – 0.2 mg (0.1 mg);

Citric acid monohydrate – 2.6 mg;

Sodium hydrogen phosphate – 4.4 mg;

Sorbitol – 35 mg;

Lavender oil – 0.2 mg;

Water – up to 1 ml.

Contraindications

Hypersensitivity to the components of the drug.

Atrophic rhinitis (including with foul-smelling discharge – ozena). Taking MAO inhibitors (simultaneously or in the previous 14 days).

Use with caution in patients with arterial hypertension, arrhythmias, cardiovascular diseases, as well as in patients with generalized atherosclerosis, thyroid diseases, angle-closure glaucoma, prostate adenoma, and insulin-dependent diabetes mellitus.

As with the use of any local vasoconstrictor, caution should be exercised when prescribing Vibrocil to patients with severe reactions to sympathomimetics (for example, the development of insomnia and dizziness).

The drug is not recommended to be taken during pregnancy without a doctor’s recommendation.

Side Effects

Mild and transient local reactions from the nasal mucosa (burning or dry feeling).

Overdose

When Vibrocil was accidentally ingested by young children, no serious side effects were observed. In most cases, there were no symptoms of overdose, however, sometimes symptoms such as a feeling of fatigue, pain in the stomach, tachycardia, arterial hypertension, agitation, insomnia, pale skin were reported (more often in children with accidental ingestion).

Treatment: use of activated carbon, laxatives (gastric lavage is not required); in adults and children over 6 years of age, take large amounts of fluid. There is no specific antidote.

Storage conditions

Store at a temperature not exceeding 30°C.

Shelf life

3 years. The drug should not be used after the expiration date marked [EXP] on the packaging.

Manufacturer

GSK Consumer Healthcare S.A., Switzerland