Vaccine, mumps and measles culture.live dry 1 dose
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It is a lyophilized mixture of liquid semi-finished products of measles and mumps vaccines prepared by culturing attenuated strains of measles virus L-16 and epidemic mumps virus L-3 on primary cell culture of quail embryos./p>
Stimulates production of antibodies to measles and mumps viruses in seronegative inoculated individuals, reaching peak values 3-4 weeks after vaccination. and 6-7 weeks after vaccination, respectively.
Indications
Prevention of measles and mumps, starting at the age of 12 months.
In accordance with the National Preventive Vaccination Calendar vaccination is carried out twice at the age of 12 months and 6 years to children who have not had measles and mumps.
Active ingredient
Measles and mumps vaccine
Composition
One inoculation dose of the drug contains:
Active ingredients:
- measles virus – at least 1,000 (3.0 lg) tissue cytopathogenic doses (TCD50);
- mumps virus – at least 20,000 (4.3 lg) TCD50.
Auxiliary substances:
- stabilizer – mixture of 0.08 ml of LS-18* aqueous solution and 0.02 ml of 10% gelatin solution;
- gentamicin sulfate – not more than 20 µg.
How to take, the dosage
Immediately prior to use, the vaccine is diluted with solvent for measles, mumps and mumps-core culture live vaccines (hereinafter referred to as solvent) at the rate of 0.5 ml of solvent per one inoculation dose of vaccine.
The vaccine must be completely dissolved within 3 minutes.
Dissolved vaccine has the appearance of a transparent pink liquid.
Vaccines or solvent in ampoules with damaged integrity, markings, as well as with changes in their physical properties (color and transparency, etc.), with expired shelf life or improperly stored are not suitable for use.
Ampoules are opened and the vaccination procedure is carried out in strict compliance with aseptic and antiseptic rules.
Ampoules with vaccine and diluent are treated with 70 0 ethyl alcohol in the incision area and are broken, while not allowing the alcohol to get into the ampoule.
To dilute the vaccine, take all the necessary volume of the solvent and transfer it to the ampoule with dry vaccine.
After mixing the vaccine is taken with another needle into a sterile syringe, which is then used for vaccination.
The vaccine is injected subcutaneously in the volume of 0.5 ml under the scapula or in the shoulder area (on the border between the lower and middle third of the shoulder on the outer side), pre-treating the skin at the injection site with 70 degree of ethanol.
Dissolved vaccine is used immediately and should not be stored.
Vaccination is recorded in the established record forms with the name of the drug, date of vaccination, dose, manufacturer, series number, expiration date, reaction to vaccination.
Interaction
Vaccination can be carried out simultaneously (on the same day) with DPT and ADS vaccines, live and inactivated polio vaccine, vaccine against hepatitis B, rubella, influenza, hemophilus infection, provided that it is administered in different parts of the body.
Other live viral vaccines are administered at intervals of at least 1 month. If a tuberculin test is necessary it should be done either simultaneously with the vaccination or 6 weeks afterwards, since the measles (and possibly mumps) vaccination process can cause temporary decreased sensitivity of the skin to tuberculin, which would cause a false negative result.
After administering human immunoglobulin preparations, vaccination should be carried out not earlier than 2 months later. After administration of mumps and measles vaccine the immunoglobulin preparations can be administered not earlier than 2 weeks later; in case it is necessary to administer immunoglobulin earlier than this period the vaccination against mumps and measles should be repeated.
Special Instructions
Given the possibility of immediate allergic reactions (anaphylactic shock, Quincke’s edema, urticaria) in especially sensitive individuals, vaccinated persons must be medically monitored for 30 minutes. Vaccination sites must be provided with anti-shock therapy.
Contraindications
Anaphylactic reactions or severe allergic reactions to aminoglycosides (gentamicin sulfate), chicken and/or quail eggs.
Primary immunodeficiency states, malignant blood diseases and neoplasms.
Severe reaction (fever above 40 0C, hyperemia and / or swelling greater than 8 cm in diameter at the injection site) or a complication of a previous administration of mumps or measles vaccines.
Pregnancy and breastfeeding period.
Acute diseases or exacerbation of chronic diseases.
Note. HIV infection is not a contraindication to vaccination.
Side effects
Most vaccinated people are asymptomatic during the vaccination process.
The following adverse reactions of varying severity may occur after vaccination:
Often (1/10 – 1/100):
- from 5 to 15 days – short-term slight increase in body temperature, catarrhal phenomena from the nasopharynx (mild pharynx hyperemia, rhinitis).
With mass administration of the vaccine, the increase in body temperature above 38.5 ° C should not be more than 2 percent of vaccinated people. An increase in body temperature above 38.5 C in the post-vaccination period is an indication for administration of antipyretics.
Infrequent (1/100 to 1/1000):
- from day 5 to day 18 – coughing, conjunctivitis, skin-like rash lasting 1-3 days.
Rare (1/1000 to 1/10000):
- in the first 48 h after vaccination, local reactions expressed as skin hyperemia and mild edema at the site of vaccine injection, which go away without treatment;
- from 5 to 42 days – short-term slight increase in parotid salivary glands lasting 2 to 3 days. – Restlessness, lethargy, sleep disturbances.
Very rare (<1/10000):
- in the first 24-48 h – allergic reactions occurring in persons with altered reactivity;
- in 6-10 days – convulsive reactions occurring after vaccination against a background of high temperature;
In case of side effects not described in the instructions, the patient should inform the doctor about them.
Weight | 0.035 kg |
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Shelf life | 1 year |
Conditions of storage | The vaccine is stored in closed rooms that protect the preparation from sunlight, moisture, mold, rodents, etc., at a temperature below 8 ° C. |
Manufacturer | Microgen NPO, Russia |
Medication form | solution for injection |
Brand | Microgen NPO |
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