Ursodez, 500 mg capsules 10 pcs.
€1.00
Out of stock
(E-mail when Stock is available)
Hepatoprotector. It has a choleretic effect. Reduces the synthesis of cholesterol in the liver, its absorption in the intestine and its concentration in the bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and excretion of bile.
Decreases the lithogenicity of bile, increases the content of bile acids in it. Causes increased gastric and pancreatic secretion and increases lipase activity. It has a hypoglycemic effect.
It causes partial or complete dissolution of cholesterol stones when taken orally, reduces the saturation of bile with cholesterol, which promotes the mobilization of cholesterol from gallstones.
It has immunomodulatory effects, influences immunological reactions in the liver: it reduces the expression of some antigens on the membrane of hepatocytes, affects the number of T-lymphocytes, interleukin-2 formation, reduces the number of eosinophils.
Indications
Gallstone disease, Liver Cirrhosis
– dissolution of small and medium cholesterol stones with a functioning gallbladder;
– biliary reflux gastritis;
– primary biliary cirrhosis in the absence of signs of decompensation (symptomatic treatment);
– chronic hepatitis of different genesis;
– primary sclerosing cholangitis;
– cystic fibrosis (cystic fibrosis);
– non-alcoholic steatohepatitis;
– alcoholic liver disease;
– biliary dyskinesia.
Active ingredient
Ursodeoxycholic acid
Composition
1 capsule – ursodeoxycholic acid 500 mg.
Interaction
Colestiramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide) reduce absorption of ursodeoxycholic acid in the intestine and thus reduce its absorption and effectiveness. If the use of drugs containing at least one of these substances is necessary, they should be taken at least 2 hours before taking Ursodez.
Ursodeoxycholic acid may enhance intestinal absorption of cyclosporine. Therefore, in patients taking cyclosporine, the concentration of cyclosporine in blood should be checked and the dose of cyclosporine should be adjusted, if necessary.
In some cases Ursodez may reduce absorption of ciprofloxacin.
Hypolipidemic drugs (especially clofibrate), estrogens, neomycin or gestagens increase bile cholesterol saturation and may decrease the ability to dissolve cholesterol-containing gallstones.
Directions for use
The drug is taken orally.
Dissolution of cholesterol gallstones
The recommended (approximate) dose is 10 mg of ursodeoxycholic acid per 1 kg of body weight per day. The drug should be taken daily in the evening before going to bed (capsules should not be chewed), with a small amount of liquid.
It usually takes 6-24 months to dissolve gallstones. If the size of the stones does not decrease after 12 months of treatment, treatment should be stopped.
The effectiveness of treatment should be evaluated every 6 months with ultrasound or radiography. In an interim evaluation, it should be assessed whether the stones have calcified since then. If stones have calcified, treatment should be stopped.
The treatment of biliary reflux gastritis
The recommended dose is 1 capsule (250 mg) of Ursodez ® daily in the evening before bedtime. The capsules should be swallowed with a small amount of water.
The course of treatment is from 10-14 days to 6 months, if necessary up to 2 years.
The symptomatic treatment of primary biliary cirrhosis
The daily dose depends on body weight and is 1 to 3 capsules (500 mg) or 2 to 6 capsules (250 mg) (about 10 to 15 mg of ursodeoxycholic acid per 1 kg of body weight) in 2-3 times, the first 3 months of treatment. After improvement of liver functional parameters, the daily dose can be used 1 time in the evening. The duration of treatment course is not limited. In rare cases at the beginning of treatment clinical symptoms may worsen (itching may become more frequent). In this case, the daily dose should be reduced (to 250 mg) and then gradually increased (increasing the daily dose weekly) until the recommended dosage regimen is achieved.
Chronic hepatitis of various genesis, nonalcoholic steatohepatitis and alcoholic liver disease
The average daily dose is from 10 to 15 mg of ursodeoxycholic acid per 1 kg of body weight in 2-3 doses. The duration of therapy is 6-12 months or more.
Primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis)
In primary sclerosing cholangitis: 12-15 mg/kg/day (up to 20 mg/kg/day) in 2-3 doses. Duration of use – from 6 months to several years.
In cystic fibrosis (cystic fibrosis): 20-30 mg/kg/day in 2-3 doses. Duration of use – from 6 months to several years.
Biliary dyskinesia
Average daily dose is 10 mg of ursodeoxycholic acid per 1 kg of body weight in 2 doses during 2 weeks to 2 months. If necessary the treatment course should be repeated. Regimen of dosing is determined by the doctor.
Calculation of the daily number of capsules depending on the patient’s body weight and recommended dose per 1 kg of body weight
. Body weight, kg | 10 mg/kg/day | 12 mg/kg/day | 15 mg/kg/day | 20 mg/kg/day | 30 mg/kg/day | ||
34-35 | 1 caps. 250 mg | 2 capsules of 250 mg or 1 capsule of 500 mg | 2 capsules of 250 mg or 1 capsule of 500 mg | 3 capsules. 250 mg | 4 capsules of 250 mg or 2 capsules of 500 mg | ||
36-40 | 2 capsules. 250 mg or 1 capsule of 500 mg | 2 capsules of 250 mg or 1 capsule of 500 mg | 2 capsules of 250 mg or 1 capsule of 500 mg | 3 capsules of 250 mg | 5 capsules of 250 mg | ||
41-45 | 2 capsules. 250 mg or 1 capsule of 500 mg | 2 capsules of 250 mg or 1 capsule of 500 mg | 3 capsules of 250 mg | 4 capsules. 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | ||
45-50 | 2 capsules. 250 mg or 1 capsule of 500 mg | 2 capsules of 250 mg or 1 capsule of 500 mg | 3 capsules. 250 mg | 4 capsules of 250 mg or 2 capsules of 500 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 6 capsules of 250 mg or 3 capsules of 500 mg. 500 mg | |
51-55 | 2 capsules of 250 mg or 1 capsule of 500 mg | 3 capsules. 250 mg | 3 capsules of 250 mg | 4 capsules of 250 mg or 2 capsules of 500 mg | 7 capsules. 250 mg | ||
56-60 | 2 capsules of 250 mg or 1 capsule of 500 mg | 3 capsules of 250 mg | 4 capsules. 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | 7 capsules of 250 mg | ||
61-65 | 3 capsules. 250 mg | 3 capsules of 250 mg | 4 capsules of 250 mg or 2 capsules of 500 mg | 5 capsules. 250 mg | 8 capsules of 250 mg or 4 capsules of 500 mg | ||
66-70 | 3 capsules. 250 mg | 3 capsules of 250 mg | 4 capsules of 250 mg or 2 capsules of 500 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 8 capsules of 250 mg or 4 capsules of 500 mg | ||
71-75 | 3 capsules. 250 mg | 4 capsules of 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 9 capsules of 250 mg | ||
76-80 | 3 capsules of 250 mg | 4 capsules. 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 10 capsules. 250 mg or 5 capsules of 500 mg | ||
81-85 | 3 capsules of 250 mg | 4 capsules. 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | 7 capsules of 250 mg | 10 capsules of 250 mg or 5 capsules of 500 mg | ||
86-90 | 4 capsules of 250 mg or 2 capsules of 500 mg | 4 capsules. 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | 7 capsules of 250 mg | 11 capsules. 250 mg | ||
91-95 | 4 capsules of 250 mg or 2 capsules of 500 mg | 5 capsules. 250 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 8 capsules of 250 mg or 4 capsules of 500 mg | 11 capsules. 250 mg | ||
96-100 | 4 capsules of 250 mg or 2 capsules of 500 mg | 5 capsules. 250 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 8 capsules of 250 mg or 4 capsules of 500 mg | 12 capsules. 250 mg or 5 capsules of 500 mg | ||
101-105 | 4 capsules of 250 mg or 2 capsules of 500 mg | 4 capsules of 250 mg or 2 capsules of 500 mg. 500 mg | 5 capsules of 250 mg | 6 capsules of 250 mg or 3 capsules of 500 mg | 8 capsules of 250 mg or 4 capsules of 500 mg | 13 capsules of 250 mg | |
105-110 | 4 capsules of 250 mg or 2 capsules of 500 mg | 5 capsules of 250 mg | 7 capsules of 250 mg | 9 capsules of 250 mg | 13 capsules. 250 mg |
In children from 3 years of age, individually (at the rate of 10-20 mg/kg/day).
Special Instructions
The use of the drug Ursodez should be under the supervision of a physician.
In the first 3 months of treatment liver functional parameters (transaminases, ALP and GGT) in serum should be monitored every 4 weeks, and then every 3 months. Monitoring of these parameters allows to detect liver dysfunction at early stages. This also applies to patients in the later stages of primary biliary cirrhosis. In addition, this is a quick way to determine if a patient with primary biliary cirrhosis is responding to ongoing treatment.
Application for dissolution of cholesterol gallstones
In order to evaluate the progress of treatment, as well as for early detection of signs of stone calcification, the gallbladder should be visualized (oral cholecystography) with observation of darkening in standing and supine position (ultrasound) 6-10 months after the start of treatment. If the gallbladder cannot be visualized on X-rays or in case of calcification of the stones, poor gallbladder contractility or frequent attacks of colic, Ursodez should not be used.
Treatment of patients with advanced stages of primary biliary cirrhosis
There have been extremely rare cases of decompensation of liver cirrhosis. After discontinuation of therapy, regression of decompensation manifestations was noted.
Long therapy with ursodeoxycholic acid in high doses (28-30 mg/kg/day) may cause serious adverse events in patients with primary sclerosing cholangitis.
In patients with diarrhea, the drug dose should be reduced. Treatment should be discontinued in persistent diarrhea.
Influence on driving and operating ability
There is no effect on driving and operating ability.
Contraindications
– X-ray-positive (high calcium) gallstones;
– non-functioning gallbladder;
– acute inflammatory diseases of the gallbladder, bile ducts and intestines;
– decompensated cirrhosis of the liver;
– marked renal dysfunction;
– marked impairment of liver function;
– marked impairment of pancreatic function;
– adults and children with a body weight up to 34 kg;
– children under 3 years of age (for this dosage form);
– hypersensitivity to the components of the drug.
With caution should the drug be prescribed in patients with cholelithiasis and cholestatic liver diseases.
Side effects
Digestive system disorders: diarrhea, nausea, pain in epigastric region and right subcostal area, calcification of gallstones, increased liver transaminase activity.
In treatment of primary biliary cirrhosis, transient decompensation of liver cirrhosis may be observed, which disappears after discontinuation of the drug.
Other: allergic reactions.
Overdose
No cases of overdose have been identified. In case of overdose symptomatic treatment is carried out.
Pregnancy use
The drug is contraindicated in pregnancy and during lactation (breastfeeding).
Similarities
Ursofalk, Ursosan, Urdoxa, Ursoliv, Exchol, Grinterol, Urcevel, Ursodeoxycholic acid
Weight | 0.018 kg |
---|---|
Shelf life | 3 years. |
Conditions of storage | The drug should be kept out of reach of children, dry and protected from light at a temperature not exceeding 25°C. |
Manufacturer | North Star NAO, Russia |
Medication form | capsules |
Brand | North Star NAO |
Other forms…
Related products
Buy Ursodez, 500 mg capsules 10 pcs. with delivery to USA, UK, Europe and over 120 other countries.