Tiloron-SZ, 125 mg 10 pcs

Low-molecular synthetic inducer of interferon stimulating formation of all types of interferons in the body (alpha, beta, gamma and lambda).

The main producers of interferon in response to tiloron administration are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration the maximum production of interferon is determined in the sequence intestine – liver – blood in 4-24 hours.

Tiloron has immunomodulatory and antiviral effect. After a single oral administration of Tiloron at a dose equivalent to the maximum daily dose for humans, the maximum concentration in the lung tissue of interferon lambda was determined after 24 hours, interferon alpha – after 48 hours.

Induction of interferon lambda in lung tissue increases antiviral protection of the respiratory tract during influenza and other respiratory viral infections.

In human leukocytes it induces interferon synthesis. Stimulates bone marrow stem cells, depending on the dose increases antibody formation, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers.

Effective against various viral infections including flu viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is connected to inhibition of translation of virus-specific proteins in infected cells, thus suppressing the reproduction of viruses.

Pharmacokinetics

After oral administration it is quickly absorbed from the gastrointestinal tract. Bioavailability is 60%. About 80% of the drug is bound to plasma proteins. The drug is eliminated practically unchanged in intestine (70%) and kidney (9%). The elimination half-life (T1/2) is 48 hours. The drug is not biotransformed and does not accumulate in the body.

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