Thiotriazolin, 25 mg/ml 4 ml 10 pcs

Thiotriazolinum is a drug with marked membrane stabilizing, antioxidant, reparative and immunomodulatory activity. Thiotriazolin also has some anti-ischemic action.

The mechanism of action of thiotriazolinum is related to the ability of the drug to enhance the compensatory activation of anaerobic glycolysis as well as to activate the oxidation processes in the Krebs cycle without changing the intracellular ATP fund.

Tiotriazolin activates the antioxidant system due to the sulfur thiol and tertiary nitrogen included in the molecule, which leads to the reduction of the negative impact of free radicals and the intensity of peroxidation processes and the formation of free oxygen ions.

Tiotriazolin reduces myocardial sensitivity to catecholamines, prevents the progressive inhibition of myocardial contractile function and also helps to reduce the zone of ischemia and myocardial necrosis.

Tiotriazolin also normalizes metabolic processes in myocardium, promotes normalization of heart rate and improves rheological properties of blood due to activation of fibrinolytic system.

Tiotriazolin has strong hepatoprotective activity, prevents the destruction of hepatocytes and stimulates their regeneration, reduces the spread of necrosis and fatty liver infiltration.

Thiotriazolin normalizes protein, pigment, carbohydrate and lipid metabolism in hepatocytes. It has some choleretic effect and normalizes the composition of bile.

In oral administration tiotriazolin is well absorbed, bioavailability reaches 53%. With single oral administration, the peak plasma concentration of tiotriazolin reaches within 1.6 hours, with intramuscular administration – 0.84 hours, intravenous administration – 0.1 hour.

The elimination half-life is about 8 hours. Tiotriazolin accumulates in the kidney tissues and to a small extent in the tissues of the lungs, colon, heart and spleen.

Indications

Stenocardia, Liver Cirrhosis, Liver Damage

• Chronic alcoholic hepatitis of minimal and moderate activity.
• Chronic viral hepatitis, fatty liver dystrophy, liver cirrhosis.
• Toxic liver lesions, including those of alcoholic and viral origin.Toxic liver damage, including alcoholic, viral and drug origin (antibiotics, antitumor, anti-tuberculosis, antiviral drugs, tricyclic antidepressants, oral contraceptives, etc.)

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Active ingredient

Morfolinium-Methyl-Triazolyl-Tioacetate

Composition

1 ml of solution for injection contains:

the active ingredient:

morpholinium-methyl-triazolyl thioacetate (thiotriazolin) 25 mg.

excipients:

water for injection

How to take, the dosage

Parenterally.

. In chronic hepatitis Tiotriazolin is administered intramuscularly 2 ml of 2.5% solution 2-3 times a day (2-3 times 50 mg), or intravenously slowly at a rate of 2 ml/min by 4 ml of 2.5% solution (100 mg) or dropwise at a rate of 20-30 drops per minute (2 ampoules of 2.5% solution dissolved in 150-250 ml of physiological solution).

From the fifth to the twentieth day of treatment we prescribe Thiotriazolin in tablets (100 mg 3 times a day).

The course of treatment is 20-30 days.

Interaction

Thiotriazolin as a cardioprotective drug can be used in combination with baseline therapy of coronary heart disease.

As a hepatoprotective agent, it can be combined with the prescription of traditional methods of treatment of hepatitis of the corresponding etiology.

Contraindications

• High sensitivity to components of the drug Tiotriazolin;
• childhood
• renal insufficiency
• pregnancy and lactation.

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Side effects

Thiotriazolinum is generally well tolerated. There have been isolated cases of adverse reactions during clinical use of Thiotriazolinum:

Gastrointestinal tract: nausea, dry mouth, bloating;

Central and peripheral nervous system: General weakness, dizziness, tinnitus;

Cardiovascular system: tachycardia, increased blood pressure, heart pain, arrhythmias;

Respiratory system: very rare – shortness of breath, episodes of choking.

Allergic reactions: hypersensitivity reactions, fever, very rare – Quincke’s edema.

Skin reactions: itching, skin hyperemia, urticaria.

Overdose

Incidents of overdose are unknown.

Pregnancy use

It is contraindicated in pregnancy and lactation.