Texamen, 20 mg

Tenoxicam is a non-steroidal anti-inflammatory drug, it has a powerful anti-inflammatory and analgesic effect, the antipyretic effect is less pronounced, and also prevents platelet aggregation. The mechanism of action is based on inhibition of cyclooxygenase isoenzymes-1 and cyclooxygenase-2 activity, which reduces the synthesis of prostaglandins in inflammation focus, as well as in other body tissues. In addition, tenoxicam reduces the accumulation of leukocytes in the focus of inflammation.
Anti-inflammatory effect develops by the end of the first week of treatment.

Pharmacokinetics.

Absorption is fast and complete (food intake slows down). Bioavailability is 100%. The maximum concentration is noted after 2 hours. A distinctive feature of tenoxicam is a long duration of action and a long elimination half-life – 72 hours. The drug is 99% bound to plasma proteins. Tenoxicam penetrates well into the synovial fluid. Easily penetrates through histohematic barriers. Metabolized in the liver by hydroxylation to form 5-hydroxytenoxicam. 1/3 is excreted in the bile, 2/3 in the urine as inactive metabolites.

Indications

pain syndrome (mild to moderate intensity):

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

During treatment it is necessary to monitor the peripheral blood picture and functional state of the liver and kidneys, prothrombin index (against the background of indirect anticoagulants), blood glucose (against the background of oral hypoglycemic drugs).
If it is necessary to determine 17-ketosteroids, the drug should be withdrawn 48 hours before the study.

A few days before surgical intervention the drug should be withdrawn.
During the treatment it is necessary to refrain from potentially dangerous activities requiring high concentration and quick psychomotor reactions.
It is necessary to consider the possibility of sodium and water retention in the body when prescribing with diuretics in patients with arterial hypertension and heart failure.
A history of renal disease may lead to the development of interstitial nephritis, papillary necrosis and nephrotic syndrome, do not use nephrotoxic drugs immediately after surgical interventions.

Contraindications

With caution: heart failure, edema, arterial hypertension, diabetes, advanced age.

Side effects

Overdose

Similarities