Teturam, tablets 150 mg 50 pcs

Teturam inhibits acetaldehyde dehydrogenase involved in ethanol metabolism; it increases the concentration of acetaldehyde, which is a metabolite of ethanol and causes a number of unpleasant symptoms after its use (“rushes” of blood to the skin, nausea, vomiting, malaise, tachycardia, BP decrease).

As a result, the development of conditioned reflex reaction of aversion to the taste and smell of ethanol takes place.

The duration of action of oral tablets is 48 hours. The use in the form of implants creates a constant concentration of the drug in the body.

Disulfiram-ethanol reactions can occur within 5-9 months after implantation. If ethanol is ingested, lipid mobilization occurs, vasodilation and increased blood flow at the implantation site, resulting in increased blood flow of disulfiram.

Indications

Active ingredient

Composition

1 tablet contains:

Teturam 150 mg.

Auxiliary substances:

Potato starch,

Stearic acid,

Aerosil.

How to take, the dosage

The treatment is prescribed after careful examination of the patient and warning about the consequences and complications. The drug is taken orally by 150-500 mg 2 times a day according to an individual scheme.

In 7-10 days we conduct tetramalcohol test (20-30 ml of 40% vodka after taking 500 mg of the preparation), in case of weak reaction the alcohol dose is increased by 10-20 ml (maximum dose of vodka is 100-120 ml).

The test is repeated in 1-2 days in the hospital and in 3-5 days on an outpatient basis, with correction of the doses of alcohol and/or the drug as necessary. Thereafter, a maintenance dose of 150-200 mg per day may be used for 1-3 years.

Interaction

Contraindicated combinations

Alcohol: intolerance reaction (hot flashes, erythema, vomiting, tachycardia). Avoid taking alcoholic beverages and medicines containing alcohol.

Indesirable combinations

Isoniazid: behavioral and coordination disorders.

Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirium disorders, confusion.
Phenytoin.: significant and rapid rise in plasma levels of phenytoin with toxic symptoms (suppression of its metabolism).
If the combination cannot be avoided, clinical observation and monitoring of plasma concentrations of the drug in entrance and after treatment with teturam should be performed.

Combinations requiring caution

Warfarin (and other oral anticoagulants): increased effect of oral anticoagulants and risk of bleeding (reduced breakdown of warfarin in the liver). More frequent monitoring of warfarin concentrations and adjustment of anticoagulant dose within 8 days of Tetum withdrawal is recommended.

Theophylline: Teturam inhibits theophylline metabolism. As a result, the dose of theophylline should be adjusted (reduced dosage), depending on clinical symptoms and plasma concentrations of the drug.

Benzodiazepines: teturam may potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.

Tricyclic antidepressants: possible exacerbation of alcohol intolerance reactions (especially if patients take alcoholic beverages while taking teturam).

Special Instructions

Patients should be warned about the risk of alcohol intolerance reactions.

Teturam should be taken with caution in patients with renal insufficiency or hypothyroidism, especially at the risk of possible combination with alcohol.

Contraindications

Absolute:

– Complicated diseases of the cardiovascular system.

– Hearing organ (neuritis of the auditory nerve).

– Visual organ (glaucoma, optic neuritis).

– Bronchial asthma.

– Pulmonary emphysema.

– Pulmonary tuberculosis.

– Severe liver failure.

– Diseases of the hematopoietic organs.

– Diabetes mellitus.

– Thyrotoxicosis.

– Epilepsy.

– Convulsive syndrome of any genesis.

– Mental illness.

– Exacerbation of peptic ulcer disease.

– Kidney disease.

– Malignant tumors.

– Polyneuritis of any etiology.

– Pregnancy.

– Increased individual sensitivity to the drug.

Relative:

– Cardiovascular diseases in the compensation stage.

– Older age (over 60 years).

– Gastric and 12 duodenal ulcer in remission.

– Residual effects after ICD.

– Previously suffered theturam (antabuse) psychosis.

Side effects

Teturam-related properties: metallic taste in the mouth, foul odor in patients with colostomy (associated with carbon sulfide), rare cases of hepatitis, sometimes seen in patients with nickel eczema without alcoholism, polyneuritis of the lower extremities, optic neuritis, memory loss, mixed consciousness, asthenia, headaches, skin allergic manifestations.

Associated with the teturam-ethyl alcohol combination: cases of respiratory failure, cardiovascular collapse, rhythm disturbances, angina pectoris, sometimes myocardial infarction, neurological disorders, brain edema have been described.

The complications of prolonged use: rare psychosis reminiscent of alcohol, hepatitis, gastritis; in persons suffering from cardiovascular disease, cerebrovascular thrombosis is possible, so if the complaints of paresthesias in the limbs and face, the drug should be immediately discontinued; exacerbation of polyneuritis.

When taking doses of alcohol over 50 – 80 ml of vodka during Teturam administration: severe cardiovascular and respiratory system disorders, edema, convulsions develop. In this case, detoxification therapy is carried out urgently, analeptics are administered, symptomatic treatment is carried out.

Overdose

Symptoms: the teturam-ethanol combination may cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.

Treatment: symptomatic.

Similarities