Tetraderm, cream 15 g

Interaction

Studies of interaction of Tetraderm with other drugs have not been conducted, but it is not recommended to use it simultaneously with other drugs for external use.

Directions for use

Externally. The cream is applied to the affected skin areas in a thin layer, gently rubbing, 2 times a day until a positive clinical result. The duration of treatment is individual; it depends on the size and localization of the lesion and severity of the disease and is usually 1-2 weeks.

In foot dermatomycosis the average duration of treatment is 2-4 weeks. It is not recommended to use Tetraderm® for more than 4 weeks. If after the treatment no improvement occurs or new symptoms appear it is necessary to consult a physician.

Use the drug only according to the way of application and in such doses as specified in the instructions.

If necessary, please consult a doctor before using the drug.

Special Instructions

Tetraderm is not intended for use in ophthalmology. Do not allow the drug to get in the eyes and on the periorbital area. Tetraderm cream is not recommended for use on the face and scalp. It is not recommended to use the drug under occlusive dressings, except in cases where it is necessary. It should not be used to treat varicose trophic ulcers of the lower leg and open wounds.

Some body regions (inguinal folds, armpits and perianal area) are more prone to the risk of occurrence of striae, therefore the duration of application of the drug to these areas of the body should be limited.

If irritation or signs of hypersensitivity are observed during the use of Tetraderm, the treatment should be stopped and the patient should undergo another therapy. Any side effects similar to those observed with systemic GCS including inhibition of adrenal cortex function may also be observed with external application of GCS. Systemic absorption of topical GCS may increase with prolonged use, treatment of large body surfaces or use of occlusive dressings.

In these cases side effects typical for systemic GCS may develop. It should be taken into consideration that GCS may change the manifestation of some skin diseases which may complicate the diagnosis. In addition, the use of GCS may cause delay in wound healing.

In case of prolonged GCS therapy abrupt discontinuation of the therapy may lead to the development of ricochet syndrome, which is manifested as dermatitis with intense reddening of the skin and burning sensation. Therefore, after a long course of treatment Tetraderm should be withdrawn gradually.

Systemic absorption of gentamicin when used externally may increase if applied to large areas of skin, especially during long-term treatment or in the presence of skin lesions.

During prolonged use of Tetraderm on large surfaces of skin with compromised integrity there is a potential possibility of absorption of gentamicin and accordingly the development of ototoxicity symptoms and other adverse events characteristic of gentamicin in its systemic use. Cross-allergic reactions to antibiotics from the group of aminoglycosides may develop.

With prolonged external use of gentamicin the growth of insensitive microflora, including fungi, may be observed. In this case, as well as in case of development of irritation, hypersensitivity reactions and superinfection, the treatment should be stopped and appropriate therapy should be prescribed.