Tavegil, tablets 1 mg 20 pcs

H1 – histamine receptor blocker, refers to the antihistamines of the group of benzohydryl ethers. It has a strong antihistamine and antipruritic effect with a rapid onset of action and duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

With antiallergic effect, it reduces vascular and capillary permeability, inhibits exudation and edema formation, reduces itching, has m-cholinoblocking effect.

Intestation

After oral administration, clemastine fumarate (clemastine) is almost completely absorbed from the gastrointestinal tract. Maximum plasma concentrations are reached after 2-4 hours. Antihistamine action of the drug reaches its maximum after 5-7 hours; as a rule, the effect lasts up to 10-12 hours, in some cases up to 24 hours.

Distribution

The binding to plasma proteins is 95%.

Metabolism

Clemastine undergoes significant metabolism in the liver.

The excretion

The plasma excretion is biphasic, with respective half-lives of 3.6 ± 0.9 h and 37 ± 16 h. Metabolites are eliminated mainly by the kidneys (45-65%); unchanged active substance is found only in trace amounts in urine.

A small amount of clemastine may penetrate into breast milk during breastfeeding.

Indications

Active ingredient

Composition

Active ingredient:

Clemastine 1 mg, which is equivalent to 1.34 mg of clemastine hydrofumarate.

Auxiliary substances:

Lactose monohydrate,

povidone (polyvinylpyrrolidone),

Corn starch,

Magnesium stearate,

Talc.

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use