Kestin, 10 mg 10 pcs.

Pharmgroup: anti-allergic agent – H1-histamine receptor blocker.

Pharmaceutical action: Long-acting blocker of histamine H1-receptors. Prevents histamine-induced spasms of smooth muscles and increased vascular permeability. After oral administration, a pronounced antiallergic effect develops in 1 hour and lasts for 48 hours. After 5-day course of treatment with Kestin antihistamine activity is maintained for 72 hours due to the action of active metabolites.

The drug does not cause significant anticholinergic and sedative effects. No effect of Kestin on QT interval duration on ECG even at a dose of 80 mg has been noted.

Indications

Allergic rhinitis, Urticaria, Skin itching, Allergy, Allergic conjunctivitis

Allergic rhinitis of different etiology (seasonal and/or year-round, both accompanied and not accompanied by allergic conjunctivitis).

The urticaria of various etiologies, including chronic idiopathic.

Active ingredient

Ebastin

Composition

Active ingredient:

Ebastin microionized 10 mg.

Excipients:

microcrystalline cellulose,

corn starch,

lactose monohydrate,

sodium carboxymethylcellulose structured,

magnesium stearate,

hydroxypropyl methylcellulose,

polyethylene glycol 6000,

titanium dioxide.

How to take, the dosage

Ingestion, regardless of meals.

• Adults and children over 12 years of age: 10-20 mg (1-2 tablets) of the drug once daily.

In case of liver dysfunction the daily dose should not exceed 10 mg.

Interaction

Concomitant use of Kestin® with ketoconazole or itraconazole and erythromycin may increase the risk of QT interval prolongation on ECG.

Rifampicin decreases the plasma concentration of ebastine and has an inhibitory effect on the antihistamine effect of ebastine.

The drug Kestin® does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol and ethanol-containing drugs.

Special Instructions

Impact on ability to operate vehicles and other mechanisms requiring high concentration

In case of adverse effects on the central nervous system, there may be minimal impairment of patients’ ability to operate vehicles and engage in other potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

• High sensitivity to the components of the drug;
• pregnancy and lactation;
children under 12 years of age;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

With caution: use in patients with prolonged QT-interval, hypokalemia, renal and/or hepatic failure.

Side effects

The following are the adverse reactions observed in clinical trials and during post-registration use of the drug, taking into account the following criteria: very common (?1/10); common (1/100 to < 1/10); infrequent (1/1000 to < 1/100); rare (1/10000 to < 1/1000); very rare (< 1/10000).

An effect on the central and peripheral nervous system:

rarely: drowsiness;

very rarely: dizziness, hypoesthesia, headache, nervousness, insomnia.

Gastrointestinal tract:

rarely: dry oral mucosa;

very rarely: vomiting, abdominal pain, nausea, dyspepsia.

Cardiovascular system disorders:

very rarely: palpitations, tachycardia.

Hepatic and biliary tract disorders:

very rare: abnormal liver function tests.

Skin and subcutaneous fat:

very rare: urticaria, rash, dermatitis.

Performance of the reproductive system:

very rare: menstrual disorders.

General and local reactions:

very rarely: edema, asthenic syndrome.

The adverse reactions observed in clinical trials in children over 12 years of age (a group of 460 children) were not different from those seen in adults.

Overdose

No clinically significant signs and symptoms have been observed in studies using high doses of ebastine (over 100 mg per day). There is no special antidote for ebastine. In case of overdose, gastric lavage, control of vital body functions and symptomatic treatment are recommended.

Pregnancy use

It is contraindicated during pregnancy and lactation.

Similarities

Espa Bastin