Tavegil, tablets 1 mg 20 pcs

H1 – histamine receptor blocker, refers to the antihistamines of the group of benzohydryl ethers. It has a strong antihistamine and antipruritic effect with a rapid onset of action and duration of up to 12 hours, prevents the development of vasodilation and contraction of smooth muscles induced by histamine.

With antiallergic effect, it reduces vascular and capillary permeability, inhibits exudation and edema formation, reduces itching, has m-cholinoblocking effect.

Intestation

After oral administration, clemastine fumarate (clemastine) is almost completely absorbed from the gastrointestinal tract. Maximum plasma concentrations are reached after 2-4 hours. Antihistamine action of the drug reaches its maximum after 5-7 hours; as a rule, the effect lasts up to 10-12 hours, in some cases up to 24 hours.

Distribution

The binding to plasma proteins is 95%.

Metabolism

Clemastine undergoes significant metabolism in the liver.

The excretion

The plasma excretion is biphasic, with respective half-lives of 3.6 ± 0.9 h and 37 ± 16 h. Metabolites are eliminated mainly by the kidneys (45-65%); unchanged active substance is found only in trace amounts in urine.

A small amount of clemastine may penetrate into breast milk during breastfeeding.

Indications

Sneezing, Skin itching, Allergic conjunctivitis, Allergy, Allergic rhinitis, Pollinosis, Urticaria, Dermatosis, Dermatitis, Increased lacrimation

• Pollinosis (hay fever, incl.
• Allergic rhinoconjunctivitis;
• Ertic hives of various origins;
• pinching, pruritic dermatoses;
• acute and chronic eczema, contact dermatitis
• drug allergies
• insect bites.

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Active ingredient

Clemastine

Composition

Active ingredient:

Clemastine 1 mg, which is equivalent to 1.34 mg of clemastine hydrofumarate.

Auxiliary substances:

Lactose monohydrate,

povidone (polyvinylpyrrolidone),

Corn starch,

Magnesium stearate,

Talc.

How to take, the dosage

1 tablet (1 mg) in the morning and in the evening is administered by mouth to adults and children over 12 years of age. In cases that are difficult to treat, the daily dose may be up to 6 tablets (6 mg).

Children aged 6-12 years are prescribed 1/2-1 tablets before breakfast and at night.

Tablets should be taken before meals with water.

Interaction

Tavegil® potentiates the effect of CNS depressant drugs (hypnotics, sedatives, tranquilizers), m-cholinoblockers, as well as ethanol.

Incompatible with concomitant administration of MAO inhibitors.

Special Instructions

To prevent distortion of the results of skin scarification tests for allergens, the drug should be canceled 72 hours before allergy testing.

The tablets contain lactose, so the drug is not recommended for patients with rare congenital diseases associated with galactose intolerance, severe lactase deficiency and impaired glucose-galactose absorption.

Pediatric use

Tavegil® in tablet form is contraindicated in children under 6 years of age. Tavegil® in the form of solution for intravenous and intravenous injections may be used for treatment of children over 1 year of age.

Effect on driving and operating machinery

Clemastine has a mild sedative effect (mild to moderate in intensity), so patients taking Tavegil® are advised to refrain from driving vehicles, operating machinery, and other activities that require increased attention and rapid psychomotor reactions.

Synopsis

Tablets white or almost white, round, flat, with a beveled edge, on one side of the tablet risk and engraved “OT”.

Contraindications

• lower respiratory tract diseases (including. bronchial asthma;
• current use of MAO inhibitors;
• children under 6 years of age;
• pregnancy;
• pregnancy (breastfeeding).pregnancy;
• pregnancy (breastfeeding);
• high sensitivity to the components of the drug.

Caution should be exercised when using Tavegil® in patients with stenotic peptic ulcer, pyloroduodenal obstruction, bladder neck obstruction, and prostatic hypertrophy accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system (including arterial hypertension, hypertension and hypertension in the arteries).
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Side effects

Definition of the frequency of adverse reactions: very frequently (≥1/10); frequently (≥1/100, < 1/10); infrequently (≥1/1000, < 1/100); rarely (≥1/10 000, < 1/1000); very rarely (< 1/10 000).
Nervous system: frequently – increased fatigability, drowsiness, sedative effect, weakness, fatigue, lethargy, impaired coordination of movements; infrequently – dizziness; rarely – headache, tremor, stimulant effect.

The digestive system: rare – dyspepsia, nausea, vomiting, gastralgia, very rare – constipation, dry mouth, in some cases – loss of appetite, diarrhea.

The respiratory system: rare – clotting of bronchial secretion and difficult phlegm discharge, a feeling of pressure in the chest and breathing difficulties, stuffy nose.

Cardio-vascular system: rare – BP lowering (especially in elderly patients), extrasystole, very rare – palpitation.

Sensory system: rare – visual perception impairment, diplopia, acute labyrinthitis, tinnitus.

Urinary system: very rarely – frequent urination, difficulty in urination.

Blood system: rare – hemolytic anemia, thrombocytopenia, agranulocytosis.

Dermatological reactions: rare – skin rash, photosensitization.

Allergic reactions: rare – anaphylactic shock.

Overdose

Symptoms: overdose of antihistamines can lead to both depressing and stimulating effects on the CNS. CNS stimulation is more often observed in children. Manifestations of anticholinergic action may also develop: dry mouth, fixed pupil dilation, blood rush to the upper trunk, gastrointestinal disorders (nausea, epigastric pain, vomiting).

Treatment: if the patient has not vomited spontaneously, it should be induced artificially (only if the patient maintains consciousness). If 3 hours or more have elapsed since ingestion, gastric lavage with an isotonic solution of sodium chloride can be given. Saline laxatives may also be given. Symptomatic therapy is also indicated.

Pregnancy use

The drug is contraindicated in pregnancy and during breast-feeding.