Sulpiride, tablets 200 mg 30 pcs

Atypical antipsychotic (neuroleptic), it also has antidepressant and antiemetic effects. Neuroleptic effect is associated with antidopaminergic action. In central nervous system sulpiride blocks mainly dopaminergic receptors of limbic system, it has little effect on neostriate system, it has antipsychotic effect.

The peripheral action of sulpiride is based on inhibition of presynaptic receptors. With an increase in the amount of dopamine in the central nervous system is associated with improvement of mood, with a decrease – the development of depression.

The antipsychotic effect of sulpiride is seen in doses greater than 600 mg per day; in doses up to 600 mg per day, stimulant and antidepressant effects predominate. Sulpiride has no significant effect on adrenergic, cholinergic, seretonin, histamine and gamma-aminobutyric acid receptors.

Sulpiride stimulates prolactin secretion and has a central antiemetic effect (suppression of the vomiting center) due to blockade of dopamine D2-receptors of the vomiting center trigger zone.

Indications

Acute psychotic disorders in adults; chronic psychotic
disorders in adults (schizophrenia, chronic non-schizophrenic
delusional states: paranoid delusion, chronic hallucinatory
psychosis).

Pharmacological effect

An atypical antipsychotic drug (neuroleptic), also has antidepressant and antiemetic effects. The neuroleptic effect is associated with an antidopaminergic effect. In the central nervous system, sulpiride predominantly blocks dopaminergic receptors of the limbic system, has a slight effect on the neostriatal system, and has an antipsychotic effect.

The peripheral effect of sulpiride is based on inhibition of presynaptic receptors. An increase in the amount of dopamine in the central nervous system is associated with an improvement in mood, and a decrease is associated with the development of depression.

The antipsychotic effect of sulpiride is manifested in doses of more than 600 mg per day; in doses up to 600 mg per day, the stimulating and antidepressant effect predominates. Sulpiride does not have a significant effect on adrenergic, cholinergic, seretonin, histamine and gamma-aminobutyric acid receptors.

Sulpiride stimulates the secretion of prolactin and has a central antiemetic effect (suppression of the vomiting center) due to the blockade of dopamine D2 receptors in the trigger zone of the vomiting center.

Special instructions

Use with caution in patients with parkinsonism and the elderly. In severe renal failure, a dose reduction or intermittent course of treatment is recommended.

In patients with epilepsy, before starting therapy, it is necessary to conduct a preliminary clinical and electrophysiological examination, because sulpiride lowers the threshold for convulsive readiness.

In case of hyperthermia, which is one of the elements of NMS, sulpiride should be discontinued immediately.

During the treatment period, avoid drinking alcohol.

Use with caution in children.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, you should refrain from engaging in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Active ingredient

Sulpiride

Composition

1 tablet contains:

Pregnancy

During pregnancy and lactation, use with caution and in minimal effective doses.

Contraindications

Children under 18 years of age.
Acute poisoning with alcohol, hypnotics, analgesics;
hyperprolactinemia;
galactosemia, glucose/galactose malabsorption syndrome or lactase deficiency;
hypersensitivity to sulpiride or another ingredient of the drug;
prolactin-dependent tumors (for example, pituitary prolactinomas and breast cancer);
pheochromocytoma;
acute porphyria;
simultaneous use of levodopa (see section “Interaction with other drugs”);
concomitant therapy with dopamine receptor agonists (cabergoline, quinagolide, ropinirole, rotigotine) (see section “Interaction with other drugs”).

Side Effects

Adverse events that develop as a result of taking sulpiride are similar to those caused by other psychotropic drugs, but the frequency of their development is generally less.

Interaction

With simultaneous use: with levodopa, the effectiveness of sulpiride is reduced; with antihypertensive drugs, their hypotensive effect is enhanced and the risk of developing orthostatic hypotension increases.

Overdose

Symptoms: dyskinesia (spasm of masticatory muscles, spastic torticollis), extrapyramidal disorders. In some cases – severe parkinsonism, coma.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30 °C

Shelf life

3 years

Manufacturer

Organika, Russia