Sulpiride, tablets 200 mg 30 pcs

Atypical antipsychotic (neuroleptic), it also has antidepressant and antiemetic effects. Neuroleptic effect is associated with antidopaminergic action. In central nervous system sulpiride blocks mainly dopaminergic receptors of limbic system, it has little effect on neostriate system, it has antipsychotic effect.

The peripheral action of sulpiride is based on inhibition of presynaptic receptors. With an increase in the amount of dopamine in the central nervous system is associated with improvement of mood, with a decrease – the development of depression.

The antipsychotic effect of sulpiride is seen in doses greater than 600 mg per day; in doses up to 600 mg per day, stimulant and antidepressant effects predominate. Sulpiride has no significant effect on adrenergic, cholinergic, seretonin, histamine and gamma-aminobutyric acid receptors.

Sulpiride stimulates prolactin secretion and has a central antiemetic effect (suppression of the vomiting center) due to blockade of dopamine D2-receptors of the vomiting center trigger zone.

Indications

Active ingredient

How to take, the dosage

Interaction

Special Instructions

With caution is used in patients with parkinsonism, the elderly. In patients with severe renal insufficiency, dose reduction or intermittent treatment is recommended.

In patients with epilepsy, a preliminary clinical and electrophysiological examination should be performed before initiating therapy, because sulpiride lowers the threshold of seizure readiness.

In case of hyperthermia, which is an element of MNS, sulpiride should be stopped immediately.

At all times during treatment, alcohol should be avoided.

With caution, use in children.

Influence on the ability to drive and operate machinery

During treatment, refrain from engaging in potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

Contraindications

Side effects

Overdose

Pregnancy use

In pregnancy and lactation, use with caution and in the lowest effective doses.

Similarities