Stopdiar, 100 mg 24 pcs.
€9.54 €8.35
Stopdiar has antimicrobial action.
Pharmacodynamics
. Nifuroxazide is a nitrofuran derivative and has antibacterial effect against gastrointestinal Gram-positive bacteria (Staphylococcus and Streptococcus) and some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli). It does not affect the composition of normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.
Nifuroxazide presumably inhibits dehydrogenase activity and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains; cross-resistance with other antibacterial drugs has not been observed either.
The effectiveness of nifuroxazide does not depend on the pH existing in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract and acts exclusively in the intestinal lumen.
Pharmacokinetics
Nifuroxazide is hardly soluble. After oral administration, it is practically not absorbed from the digestive tract and has no systemic effect. It is excreted through the intestine.
Indications
Acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae), as well as some gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp.).
Pharmacological effect
Stopdiar has an antimicrobial effect.
Pharmacodynamics
Nifuroxazide is a nitrofuran derivative that has an antibacterial effect against gastrointestinal gram-positive bacteria (staphylococci and streptococci) and some gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli). Does not affect the composition of the normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.
Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains, and cross-resistance with other antibacterial drugs has not been observed.
The effectiveness of nifuroxazide does not depend either on the pH existing in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract and acts exclusively in the intestinal lumen.
Pharmacokinetics
Nifuroxazide is sparingly soluble. After oral administration, it is practically not absorbed from the digestive tract and has no systemic effect. Excreted through the intestines.
Special instructions
During treatment, it is necessary to replenish fluid loss orally or parenterally, depending on the patient’s condition.
Drinking alcoholic beverages during treatment with nifuroxazide may cause a disulfiram-like reaction.
Impact on the ability to drive vehicles and operate machinery. The drug does not affect the ability to drive a car or operate other mechanisms.
Active ingredient
Nifuroxazide
Composition
1 film-coated tablet contains:
Active substance:
nifuroxazide 100 mg.
Excipients:
colloidal silicon dioxide (Aerosil hydrophilic 200) 3.0 mg,
potato starch 179.0 mg,
gelatin 11.0 mg,
talc 6.0 mg,
magnesium stearate 1.0 mg.
Tablet shell:
hypromelose 3.0 mg,
titanium dioxide 0.252 mg,
talc 0.062 mg,
polyethylene glycol 20,000 0.201 mg,
quinoline yellow dye 0.112 mg.
Pregnancy
Use with caution during pregnancy and lactation.
Contraindications
Allergic reactions to 5-nitrofuran derivatives; children under 6 years of age.
Side Effects
Nifuroxazide was well tolerated, and virtually no side effects were observed.
In isolated cases, in the presence of increased individual sensitivity to nifuroxazide, abdominal pain, nausea and increased diarrhea are possible (these symptoms do not require special treatment and discontinuation of the drug).
Interaction
Due to the fact that nifuroxazide is not absorbed from the digestive tract, the possibility of interaction with other drugs is unlikely.
Storage conditions
In a dry place, protected from light, at a temperature of 15–25 °C
Shelf life
4 years
Manufacturer
Gedeon Richter, Hungary
Shelf life | 4 years |
---|---|
Conditions of storage | In a dry, light-protected place at 15-25 °C |
Manufacturer | Gedeon Richter, Hungary |
Medication form | pills |
Brand | Gedeon Richter |
Other forms…
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