Stopdiar, 100 mg 24 pcs.

Stopdiar has antimicrobial action.

Pharmacodynamics

. Nifuroxazide is a nitrofuran derivative and has antibacterial effect against gastrointestinal Gram-positive bacteria (Staphylococcus and Streptococcus) and some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli). It does not affect the composition of normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.

Nifuroxazide presumably inhibits dehydrogenase activity and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains; cross-resistance with other antibacterial drugs has not been observed either.

The effectiveness of nifuroxazide does not depend on the pH existing in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract and acts exclusively in the intestinal lumen.

Pharmacokinetics

Nifuroxazide is hardly soluble. After oral administration, it is practically not absorbed from the digestive tract and has no systemic effect. It is excreted through the intestine.

Indications

Acute and chronic diarrhea caused by intestinal Gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae) and some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp.)

Active ingredient

Composition

1 film-coated tablet contains:

Active substances:

Nifuroxazide 100 mg.

Associates:

Silicon dioxide colloid (Aerosil hydrophilic 200) 3.0 mg,

Potato starch 179.0 mg,

gelatin 11.0 mg,

talc 6.0 mg,

magnesium stearate 1.0 mg.

Pill coating:

Hypromelose 3.0 mg,

Titanium dioxide 0.252 mg,

Talc 0.062 mg,

How to take, the dosage

Stopdiar is recommended to be taken orally.

Adults and children over 14 years of age take 200 mg every 6 hours.

The course of treatment is not more than 3 days.

When treating acute diarrhea with the drug, continuous oral or intravenous replenishment of fluid deficit in the body is required depending on the general state of the patient.

Interaction

Due to the fact that nifuroxazide is not absorbed from the digestive tract, the possibility of interaction with other drugs is unlikely.

Special Instructions

During treatment it is necessary to replenish fluid loss orally or parenterally, depending on the patient’s condition.

The consumption of alcoholic beverages during treatment with Nifuroxazide may cause a disulfiram-like reaction.

Impact on the ability to drive vehicles and operate machinery. The drug does not affect the ability to drive vehicles and operate other mechanisms.

Contraindications

Allergic reactions to 5-nitrofuran derivatives; children under 6 years of age.

Side effects

Nifuroxazide is well tolerated, side effects were practically not observed.

In single cases, in the presence of hypersensitivity to nifuroxazide, abdominal pain, nausea and increased diarrhea are possible (these symptoms do not require special treatment and discontinuation of the drug).

Pregnancy use

With caution use in pregnancy and lactation.

Similarities