Stopdiar, 220 mg/5 ml suspension 90 ml

Pharmacodynamics

Nifuroxazide – intestinal antiseptic, 5-nitrofuran derivative; active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobials): Gram-positive (family Staphylococcus) and Gram-negative (family Enterobacteriaceae: Escherichia, Citrobacter, Enterobacter, Klebsiella, Salmonella, Shigella, Proteus, Yersinia), and Vibrio cholerae. It is not active against bacteria of the genus Pseudomonas and the genus Proteus (species Proteus inconstans), as well as subgroup A strains of Providentia alcalifaciens. It is assumed that the drug inhibits dehydrogenase activity and disrupts protein synthesis in pathogenic bacteria. In medium therapeutic doses it has bacteriostatic activity, and in higher doses it has bactericidal activity. The effect is seen from the first hours of treatment.

In therapeutic doses it practically does not disturb the balance of the symbiotic bacterial flora of the intestine; does not cause development of the resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents which allows to prescribe it in complex therapy with systemic agents if necessary for generalized infections. In intestinal infections of viral genesis it prevents the development of bacterial superinfection.

Pharmacokinetics

After oral administration it is practically not absorbed from the digestive tract, creating a high concentration of the active substance in the intestine. Due to these pharmacokinetic peculiarities the drug produces exclusively enteric antiseptic action, it has no systemic antibacterial activity and no general toxic effects; it is excreted with feces. The drug has no effect on clinical and biochemical parameters of blood analysis.

Indications

Acute and chronic diarrhea caused by intestinal Gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophylus influenzae) and some Gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp.)

Active ingredient

Nifuroxazide

Composition

5 ml of suspension contain:

Active substances:

Nifuroxazide 220 mg.

Associates:

carbomer – 11 mg,

saccharose – 1100 mg,

sodium hydroxide – 2.2 mg,

citric acid monohydrate – 0.83 mg,

Simethicone 30% emulsion (anti-foaming emulsion) – 11 mg,

methylparahydroxybenzoate – 5.5 mg,

Banana flavoring – 4.57 mg,

water – up to 5 ml.