Glevo, 500 mg 5 pcs.

Indications

Sinusitis, maxillary sinusitis, bronchitis, respiratory tract infections, prostatitis, tuberculosis, urinary tract infections, skin infections, pneumonia, furuncles Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
– ENT-organ infections (including acute sinusitis)
– lower respiratory tract infections (including acute sinusitis).Infections of the ENT-organs (including acute sinusitis);
– Lower respiratory tract infections (including Acute exacerbation of chronic bronchitis, community-acquired pneumonia);
– Uncomplicated and complicated infections of the urinary tract and kidneys (including Infections of genitals;
– Skin and soft tissue infections (suppurated atheromas, abscesses, furunculosis);
– Abdominal infections (in combination with drugs acting on anaerobic microflora).

Active ingredient

Levofloxacin

Composition

Levofloxacin (as hemihydrate)500 mg

Associates: Microcrystalline cellulose, povidone (K-30), crosspovidone, magnesium stearate, microcrystalline cellulose (avicel pH101).

Composition of film coating: Hypromellose, macrogol (polyethylene glycol 6000), dibutyl phthalate, talc, titanium dioxide, iron oxide red dye, iron oxide yellow dye.

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How to take, the dosage

The drug is taken orally 1-2 Tablets should be swallowed whole, without chewing and with plenty of liquid (0.5 to 1 cup). The drug may be taken before meals or between meals.
Doses are determined by the nature and severity of the infection, as well as the sensitivity of the suspected pathogen.
In patients with normal or moderately reduced renal function (CK > 50 ml/min) the following dosage regimen is recommended.
In sinusitis patients are prescribed by 500 mg once a day during 10-14 days.
In exacerbation of chronic bronchitis – by 250 mg or 500 mg once a day during 7-10 days.
In community-acquired pneumonia – 500 mg 1-2 times for 7-14 days.
In uncomplicated urinary tract infections – 250 mg once/ for 3 days.
In prostatitis – 500 mg once/ for 28 days.
In complicated urinary tract infections, including pyelonephritis – 250 mg once daily for 7-10 days.
In infections of the skin and soft tissues – 250-500 mg once daily for 7-14 days.
In case of infections of the abdominal cavity – 500 mg once/ for 7-14 days (in combination with antibacterials acting on anaerobic flora).
The following dosing regimen is used in patients with impaired renal function.
After hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) no additional doses are required.
In patients with impaired hepatic function no special dosage adjustment is required because levofloxacin is metabolized only to a very small extent in the liver. If the drug is missed it should be taken as soon as possible before the next dose is due. Then continue taking the drug according to the regimen.

Interaction

In concomitant use levofloxacin increases T1/2 of cyclosporine.

The action of the drug is reduced by intestinal motility depressant drugs, sucralfate, aluminum/magnesium-containing antacid drugs and iron salts (a break of at least 2 hours between doses is necessary).

Concomitant use of Glevo with NSAIDs, theophylline increases seizure activity.

The simultaneous use of Glevo with GCS increases the risk of tendon rupture.

Cimetidine and drugs that block tubular secretion slow the excretion of levofloxacin.

The simultaneous use of hypoglycemic agents with levofloxacin may lead to hypo- and hyperglycemia. Therefore, strict control of blood glucose levels is necessary.

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Special Instructions

Although levofloxacin is more soluble than other quinolones, patients should be adequately hydrated.

At the time of treatment, sunlight and artificial UV exposure should be avoided to avoid damage to the skin (photosensitization).

In case of signs of tendinitis, pseudomembranous colitis, levofloxacin should be stopped immediately and appropriate therapy should be prescribed.

It should be noted that patients with a history of brain damage (stroke, severe trauma) may have seizures; with insufficiency of glucose-6-phosphate dehydrogenase the risk of hemolysis increases.

Influence on driving and operating machinery

At the time of treatment, caution should be exercised while driving motor transport and engaging in other potentially dangerous activities requiring increased concentration and rapid psychomotor reactions.

Contraindications

– epilepsy;
– tendon affection in previous treatment with quinolones;
– pregnancy;
– lactation (breastfeeding);
– childhood and adolescence (under 18 years);
– hypersensitivity to levofloxacin and other fluoroquinolones.

With caution the drug should be administered in elderly patients (due to high possibility of accompanying renal function decrease), with glucose-6-phosphate dehydrogenase deficiency.