Solpadein Fast, 65 mg+500 mg 12 pcs

Analgesic-antipyretic of combined composition, contains a combination of two active ingredients: paracetamol and caffeine.

It has antipyretic and analgesic effect.

Paracetamol blocks COX in the CNS, affecting the centers of pain and thermoregulation (in inflamed tissues cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effects.

Indications

Active ingredient

Composition

Active substances:

– paracetamol 500 mg;

– caffeine 65 mg.

Auxiliary substances:

Pregelatinized starch 50 mg,

corn starch 41.4 mg,

povidone 2 mg,

potassium sorbate 0.6 mg,

talc 15 mg,

stearic acid 5 mg,

croscarmellose sodium 10 mg,

hypromellose 5 mg,

triacetin 1 mg.

How to take, the dosage

It is not recommended to use the drug for more than five days as an analgesic and for more than three days as an antipyretic without physician’s prescription and supervision.

Interaction

The drug increases the effect of MAO inhibitors. Barbiturates, carbamazepine, phenytoin, primidone, ethanol, rifampicin, phenylbutazone, preparations of Hypericum, tricyclic antidepressants and other inducers of microsomal oxidation increase production of hydroxylated active metabolites, causing possible severe liver damage in small overdoses of paracetamol (5 g or more).

Under the influence of paracetamol the elimination time of chloramphenicol is increased by 5 times.

Caffeine accelerates absorption of ergotamine.

The drug may decrease the efficacy of uricosuric drugs.

Special Instructions

Deficiency of glutathione due to eating disorders, cystic fibrosis, HIV infection, starvation, malnutrition can cause severe liver damage in small overdoses of paracetamol (5 g or more).

In patients with atonic bronchial asthma, pollinosis, there is an increased risk of allergic reactions. In patients with renal and renal insufficiency the drug should be used with caution and only after consultation with the physician. When taking the drug in patients with non-alcoholic cirrhosis there is a high risk of overdose.

When uric acid and blood glucose tests are performed, the physician should be informed about taking the drug.

The results of doping control tests of athletes may be altered by taking the drug.

Synopsis

Contraindications

Side effects

In the recommended doses, the drug is usually well tolerated.

Frequency determination of side effects: very frequently (≥1/10), frequently (≥1/100 and < 1/10), infrequently (≥1/1000 and < 1/100), rarely (≥1/10 000 and < 1/1000), very rarely (≥1/100 000 and < 1/10 000).

The following side effects were detected spontaneously during post-registration use of the drug.

Paracetamol

Allergic reactions: very rare – skin rash, angioedema (Quincke’s edema), Stevens-Johnson syndrome, anaphylaxis.

Hematopoietic system: very rarely – leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia.

In the respiratory system: very rare – bronchospasm (in patients with hypersensitivity to acetylsalicylic acid and NSAIDs).

Hepatobiliary system disorders:very rare – impaired liver function.

In prolonged use in high doses, the probability of hepatotoxic effects, nephrotoxic effects and pancytopenia increases. Also, in cases of prolonged use in high doses, monitoring of blood counts is necessary.

Caffeine

Possible: dyspeptic complaints (including nausea, epigastric pain), increased excitability, dizziness, sleep disturbances, tachycardia. If excessive consumption of caffeine-containing food products (including tea, coffee) during drug administration, anxiousness, irritability, insomnia, headache, digestive system disorders, tachycardia, cardiac arrhythmia may occur.

If any of the side effects listed above occur, stop taking the drug and see a physician immediately.

Overdose

Pregnancy use

Similarities