Solpadein Fast, 65 mg+500 mg 12 pcs

Analgesic-antipyretic of combined composition, contains a combination of two active ingredients: paracetamol and caffeine.

It has antipyretic and analgesic effect.

Paracetamol blocks COX in the CNS, affecting the centers of pain and thermoregulation (in inflamed tissues cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effects.

Indications

Myositis, Headache, Back pain, Pain, Sciatica, Sore throat, Pain after injuries and operations, Neck pain, Osteochondrosis, Neuritis, Radiculitis, Lumbago, Toothache, Migraine, Colds, Flu

Active ingredient

Caffeine, Paracetamol

Composition

Active substances:

– paracetamol 500 mg;

– caffeine 65 mg.

Auxiliary substances:

Pregelatinized starch 50 mg,

corn starch 41.4 mg,

povidone 2 mg,

potassium sorbate 0.6 mg,

talc 15 mg,

stearic acid 5 mg,

croscarmellose sodium 10 mg,

hypromellose 5 mg,

triacetin 1 mg.

How to take, the dosage

Soluble tablets Solpadein Fast should be dissolved in at least 100 ml (half a glass) of water before oral administration. Adults (including elderly) and children over 12 years old are prescribed 1-2 tablets. 3-4 times a day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

It is not recommended to use the drug for more than five days as an analgesic and for more than three days as an antipyretic without physician’s prescription and supervision.

Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Interaction

When taking regularly for a long time, the drug increases the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Episodic use of a single dose of the drug has no significant effect on the effect of indirect anticoagulants.

The drug increases the effect of MAO inhibitors. Barbiturates, carbamazepine, phenytoin, primidone, ethanol, rifampicin, phenylbutazone, preparations of Hypericum, tricyclic antidepressants and other inducers of microsomal oxidation increase production of hydroxylated active metabolites, causing possible severe liver damage in small overdoses of paracetamol (5 g or more).

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic effects.

Under the influence of paracetamol the elimination time of chloramphenicol is increased by 5 times.

Caffeine accelerates absorption of ergotamine.

Concomitant administration of paracetamol and alcoholic beverages increases the risk of hepatotoxic effects and acute pancreatitis.
Metoclopramide and domperidone increase and colestyramine decreases the rate of absorption of paracetamol.

The drug may decrease the efficacy of uricosuric drugs.

Special Instructions

If while taking the drug, improvement of the condition is not observed or the headache becomes permanent, it is necessary to consult a doctor.

While taking the drug, excessive consumption of caffeine-containing food products (including tea, coffee) is not recommended, because it may lead to anxiety, anxiety, irritability, insomnia, headache, gastrointestinal disorders, tachycardia, cardiac arrhythmia.

In cases of prolonged use in high doses, blood picture monitoring is necessary.

Deficiency of glutathione due to eating disorders, cystic fibrosis, HIV infection, starvation, malnutrition can cause severe liver damage in small overdoses of paracetamol (5 g or more).

The drug should not be taken simultaneously with other paracetamol-containing drugs.

To avoid toxic liver damage, paracetamol should not be combined with the intake of alcoholic beverages and should not be taken by persons who are prone to chronic alcohol consumption.

In patients with atonic bronchial asthma, pollinosis, there is an increased risk of allergic reactions. In patients with renal and renal insufficiency the drug should be used with caution and only after consultation with the physician. When taking the drug in patients with non-alcoholic cirrhosis there is a high risk of overdose.

When uric acid and blood glucose tests are performed, the physician should be informed about taking the drug.

The results of doping control tests of athletes may be altered by taking the drug.

Synopsis

White film-coated tablets, capsule-shaped with a flat edge, with embossed triangle mark and “+” on one side of the tablet.

Contraindications

• severe liver dysfunction;
• severe renal dysfunction;
• arterial hypertension;
• glaucoma;
• sleep disorders;
• Epilepsy;
• children under 12 years of age;
• high sensitivity to the components of the drug.

The drug should be used with caution in benign hyperbilirubinemia (including Gilbert syndrome), viral hepatitis, alcoholic liver injury, glucose-6-phosphate dehydrogenase deficiency, alcoholism.

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Side effects

In the recommended doses, the drug is usually well tolerated.

Frequency determination of side effects: very frequently (≥1/10), frequently (≥1/100 and < 1/10), infrequently (≥1/1000 and < 1/100), rarely (≥1/10 000 and < 1/1000), very rarely (≥1/100 000 and < 1/10 000).

The following side effects were detected spontaneously during post-registration use of the drug.

Paracetamol

Allergic reactions: very rare – skin rash, angioedema (Quincke’s edema), Stevens-Johnson syndrome, anaphylaxis.

Hematopoietic system: very rarely – leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia.

In the respiratory system: very rare – bronchospasm (in patients with hypersensitivity to acetylsalicylic acid and NSAIDs).

Hepatobiliary system disorders:very rare – impaired liver function.

In prolonged use in high doses, the probability of hepatotoxic effects, nephrotoxic effects and pancytopenia increases. Also, in cases of prolonged use in high doses, monitoring of blood counts is necessary.

Caffeine

Possible: dyspeptic complaints (including nausea, epigastric pain), increased excitability, dizziness, sleep disturbances, tachycardia. If excessive consumption of caffeine-containing food products (including tea, coffee) during drug administration, anxiousness, irritability, insomnia, headache, digestive system disorders, tachycardia, cardiac arrhythmia may occur.

If any of the side effects listed above occur, stop taking the drug and see a physician immediately.

Overdose

Symptoms due to paracetamol: within 24 hours, pale skin, nausea, vomiting, anorexia, stomach pain may occur; 1-2 days later there may be signs of liver damage (pain in the liver area, increased activity of liver enzymes). There may be disorders of carbohydrate metabolism and signs of metabolic acidosis.

Pregnancy use

Solpadein Fast contains caffeine. If caffeine is taken, there is a high risk of having a baby with low body weight, the risk of spontaneous abortion.

Similarities

Migraineum