Sodium tetraborate, 20% solution 30 g

Pharmacotherapeutic group: antiseptic.

TATX code: D08AD.

Pharmacological properties

Pharmacodynamics

Antiseptic agent. It has bacteriostatic activity. It is effective for candidiasis. Removes fungus mycelia from mucous membranes, disrupts the process of attachment of the fungus to the mucous membranes and inhibits its reproduction (it is not an antifungal drug, as it does not have fungicidal or fungistatic action). As an antimicrobial drug, it is part of combined preparations for the treatment of inflammatory diseases of the upper respiratory tract. It has insecticidal properties (class IV toxicity).

Pharmacokinetics

It is absorbed in the gastrointestinal tract and through the damaged skin. It is deposited in the bone tissue and the liver. It is excreted unchanged by the kidneys and through the intestine within 1 week.

Indications

Candidal lesions of the mucous membrane of the oral cavity, pharynx, upper respiratory tract, urinary tract and genital organs; diaper rash, bedsores.

Pharmacological effect

Pharmacotherapeutic group: antiseptic.

ATX code: D08AD.

Pharmacological properties

Pharmacodynamics

Antiseptic. Has bacteriostatic activity. Effective against candidiasis. Removes fungal mycelium from mucous membranes, disrupts the process of attachment of the fungus to mucous membranes and inhibits its reproduction (it is not an antifungal drug, because it does not have a fungicidal or fungistatic effect). As an antimicrobial drug, it is included in combination drugs for the treatment of inflammatory diseases of the upper respiratory tract. Has insecticidal properties (IV toxicity class).

Pharmacokinetics

Absorbed into the gastrointestinal tract and through damaged skin. Deposited in bone tissue and liver. It is excreted unchanged by the kidneys and through the intestines within 1 week.

Special instructions

The condition for effectiveness in monotherapy of vaginal candidiasis is the need for medical procedures to be carried out by medical personnel and multiple treatments; otherwise, fungal cells may linger in the vaginal crypts and lead to relapse.

Impact on the ability to drive vehicles and machinery:

No information available.

Composition

Active ingredient: sodium tetraborate decahydrate – 20 g; excipient: glycerol (glycerin) – 80 g.

Pregnancy

The use of the drug is contraindicated in pregnant women during lactation.

Contraindications

Hypersensitivity to the components of the drug, pregnancy, lactation, children under 3 years of age. Violation of the integrity of the skin (during skin processing).

Side Effects

Hyperemia and burning sensation at the site of application of the drug.

Interaction

Not studied.

Overdose

Overdose when applied topically. Symptoms of overdose with local use of the drug are unlikely. There is no information about cases of overdose with local use.
Overdose due to accidental ingestion of the drug. Lethal dose for adults – 10 – 20 g, toxic concentration in blood – 40 mg/l, lethal concentration – 50 mg/l. The following symptoms are possible: abdominal pain, vomiting, loss of appetite, diarrhea, dehydration, weakness, confusion, dermatitis, menstrual irregularities, anemia, twitching of the muscles of the face and limbs, alopecia, dysfunction of the heart, liver and kidneys. Treatment of an overdose when taking the drug orally includes: gastric lavage, forced diuresis, in case of severe poisoning – hemodialysis, IM – riboflavin mononucleotide 10 mg/day, correction of water-electrolyte balance and acidosis: IV infusion of sodium bicarbonate solution, plasma-substituting solutions, sodium chloride and dextrose solution. For abdominal pain – subcutaneously 1 ml of 0.1% atropine solution, 1 ml of 0.2% platyphylline solution, 1 ml of 1% promedol solution, IV – dextrose-procaine mixture (50 ml of 2% procaine solution and 500 ml of 5% dextrose solution). Maintaining the functions of the cardiovascular system.

Storage conditions

In a place protected from light at a temperature not exceeding 30°C.
Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date stated on the label.

Manufacturer

Samaramedprom JSC, Russia