Sodium sulfacyl-SOLOPHARM, eye drops 20% 5 ml

Pharmacodynamics:

Antimicrobial bacteriostatic agent, sulfonamide. Mechanism of action is based on competitive antagonism with paraaminobenzoic acid, inhibition of dihydropteroat synthetase and disruption of tetrahydrofolic acid synthesis, necessary for purines and pyrimidines synthesis.

Active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp, Vibrio cholerae, Clostridium perfringers, Bacillus anthracis, Corynoebacterium diphtheriae, Yersinia pestis, Chlamydia spp, Actinomyces israelii, Toxoplasma gondii.

The development of resistance to sulfacetamide is possible.

Indications

In the complex therapy of diseases of the eyelids, conjunctiva, cornea, anterior segment of the vasculature and lacrimal ducts caused by microorganisms sensitive to sulfacetamide.

For prevention of infectious complications in the treatment of burns and injuries of the visual organ.

Active ingredient

Sulfacetamide

Composition

1 ml contains:

The active ingredients:

Sodium sulfacetamide monohydrate (in terms of sodium sulfacetamide) 200 mg

Associates:

Sodium thiosulfate pentahydrate – 1 mg,

Hydrochloric acid 1M solution – to pH 8.0,

d/i water – up to 1 ml.

How to take, the dosage

Put 1 -2 drops in the conjunctival sac 6-8 times a day (every 2-3 hours). The course of treatment is 7-10 days. The number of instillations may be reduced as the condition improves. During therapy of eye diseases caused by Chlamydia trachomatis the dosing regimen is 1 drop every 2 hours, local application of sulfonamide should be combined with systemic therapy.

Interaction

Sulfacetamide increases the effect of indirect anticoagulants. Concomitant use with procaine, tetracaine, benzocaine reduces the bacteriostatic effect of sulfacetamide.

Diphenin, para-aminosalicylic acid (PASC), salicylates increase its toxicity.

Incompatible with silver salts.

Special Instructions

Patients with hypersensitivity to furosemide, thiazide diuretics, sulfonylurea or carbohydrate inhibitors may have hypersensitivity to sulfacetamide.

The overgrowth of microorganisms insensitive to sulfonamide as well as fungal flora is possible.

The antibacterial activity of sulfonamides is reduced in the presence of high concentrations of naraaminobenzoic acid in the presence of large amounts of purulent discharge.

The therapy with sulfonamides should be discontinued if allergy symptoms occur, as well as if pain and other signs of infectious inflammatory process increase, the amount of purulent discharge increases.

If vision gets blurred after injection, the patient should not drive a vehicle or engage in potentially dangerous activities requiring high concentration and quick psychomotor reaction before visual acuity is restored.

Contraindications

Individual hypersensitivity to the drug components, children (under 2 months).

Side effects

Allergic reactions, burning, lacrimation, thread, itching in the eyes, transient blurred vision after injection, nonspecific conjunctivitis, development of superinfection, severe allergic reactions to sulfonamides (Stephen-Johnson syndrome, toxic epidermolysis, fulminant liver necrosis, agranulocytosis, aplastic anemia).

If any of the side effects listed in the instructions worsen or if you notice any other side effects not specified in the instructions, inform your doctor.

Overdose

Cases of drug overdose have not been described.

Pregnancy use

Administration of the drug during pregnancy is possible only when the estimated benefit to the mother exceeds the potential risk to the fetus. Refrain from breastfeeding during the use of the drug due to the lack of relevant clinical data.

The development of nuclear jaundice in infants whose mothers took tablet forms of sulfonamides during pregnancy is possible, so the risk of jaundice when taking sulfonamide in the dosage form of eye drops cannot be excluded.

Similarities

Sulfacyl sodium eye drops, Sulfacyl sodium Renewal