Sodium sulfacyl-SOLOPHARM, eye drops 20% 5 ml

Sodium sulfacyl-SOLOPHARM, eye drops 20% 5 ml

Name: Sodium sulfacyl-SOLOPHARM, eye drops 20% 5 ml
SKU: 280821
Availability: InStock

€3.78

EAN: 4680013242961 SKU: 280821 Categories: Eye Treatment, Infections and inflammations, Medicine

Description

Pharmacotherapeutic group: Antimicrobial agent – sulfonamide.

ATC: A.07.A.B Sulfonamides

Pharmacodynamics:

Antimicrobial bacteriostatic agent, sulfonamide. Mechanism of action is based on competitive antagonism with paraaminobenzoic acid, inhibition of dihydropteroat synthetase and disruption of tetrahydrofolic acid synthesis, necessary for purines and pyrimidines synthesis.

Active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp, Vibrio cholerae, Clostridium perfringers, Bacillus anthracis, Corynoebacterium diphtheriae, Yersinia pestis, Chlamydia spp, Actinomyces israelii, Toxoplasma gondii.

The development of resistance to sulfacetamide is possible.

Pharmacokinetics:

It penetrates into the eye tissue, where it has its specific antibacterial effect. It acts mainly locally, but part of the drug is absorbed through the inflamed conjunctiva and enters the systemic bloodstream. The amount of the drug that enters the systemic bloodstream is not sufficient for development of the systemic therapeutic effect, but it is sufficient for sensitization during re-injection. When applied topically, the maximum concentration (Cmax) of sulfonamides in the cornea (about 3 mg/ml), anterior chamber humour (about 0.5 mg/ml) and iris (about 0.1 mg/ml) is reached within the first 30 minutes after application. Some amount (less than 0.5 mg/ml) persists in the eyeball tissues for 3-4 hours. When corneal epithelium is damaged sulfonamide penetration increases.

Sulfacetamide is metabolized in the liver by N-acetylation, metabolites have antibacterial activity.

Excretion of sulfacetamide occurs in the kidneys by glomerular filtration.

Indications

In the complex therapy of diseases of the eyelids, conjunctiva, cornea, anterior segment of the vasculature and lacrimal ducts caused by microorganisms sensitive to sulfacetamide.

For prevention of infectious complications in the treatment of burns and injuries of the visual organ.

Active ingredient

Composition

1 ml contains:

The active ingredients:

Sodium sulfacetamide monohydrate (in terms of sodium sulfacetamide) 200 mg

Associates:

Sodium thiosulfate pentahydrate – 1 mg,

Hydrochloric acid 1M solution – to pH 8.0,

d/i water – up to 1 ml.

How to take, the dosage

Interaction

Special Instructions

Patients with hypersensitivity to furosemide, thiazide diuretics, sulfonylurea or carbohydrate inhibitors may have hypersensitivity to sulfacetamide.

The overgrowth of microorganisms insensitive to sulfonamide as well as fungal flora is possible.

The antibacterial activity of sulfonamides is reduced in the presence of high concentrations of naraaminobenzoic acid in the presence of large amounts of purulent discharge.

The therapy with sulfonamides should be discontinued if allergy symptoms occur, as well as if pain and other signs of infectious inflammatory process increase, the amount of purulent discharge increases.

If vision gets blurred after injection, the patient should not drive a vehicle or engage in potentially dangerous activities requiring high concentration and quick psychomotor reaction before visual acuity is restored.

Additional information

Weight	0.010 kg
Shelf life	2 years. After opening the bottle – 1 month. Do not use after the expiration date!
Conditions of storage	At a temperature not higher than 15 ° C. Keep out of reach of children.
Manufacturer	Grotex Ltd, Russia
Medication form	eye drops
Brand	Grotex Ltd