Sinaflan, ointment 0.025% 10

Glucocorticosteroid for external use.

It has anti-inflammatory, anti-allergic, antiexudative and antipruritic effect.

It reduces manifestations and eliminates inflammatory skin reactions.

Pharmacokinetics

After absorption from the skin surface it is bound with plasma proteins and metabolized in liver with formation of inactive metabolites. It is excreted mainly by the kidneys.

Indications

— Eczema,

— Atopic dermatitis,

— Simple chronic lichen (limited neurodermatitis),

— Toxidermy,

— Simple allergic dermatitis,

— Seborrheic dermatitis,

— Skin itching,

— Urticaria,

— Pruritus,

— Diaper rash,

— Exudative erythema multiforme,

— Psoriasis (exudative form);

— Lichen planus,

— Discoid lupus erythematosus,

— Dyshidrosis of the hands,

— Otitis externa,

— Burns of the 1st degree,

– Insect bites.

Pharmacological effect

Glucocorticosteroid for external use.

It has anti-inflammatory, antiallergic, antiexudative and antipruritic effects.

Reduces symptoms and eliminates inflammatory skin reactions.

Pharmacokinetics

After absorption from the surface of the skin, it binds to plasma proteins and is metabolized in the liver to form inactive metabolites. It is excreted primarily by the kidneys.

Special instructions

Use only in short courses on small areas of skin.

The drug should not be applied to the face. Avoid getting the drug into your eyes.

The duration of administration in children should not exceed 5 days. It is recommended to wear loose clothing during treatment.

In patients with acne vulgaris or rosacea, the disease may worsen during treatment.

To prevent local infectious complications, it is recommended to prescribe in combination with antimicrobial agents.

Active ingredient

Fluocinolone acetonide

Composition

1 g ointment contains:

Active ingredient:

Fluocinolone acetonide (sinaphlan) – 0.25 mg,

Excipients:

Propylene glycol – 49.75 mg,

Ceresin – 50.00 mg,

Lanolin – 50.00 mg,

Vaseline – up to 1.0 g.

Contraindications

Hypersensitivity to the components of the drug; bacterial, viral, fungal skin diseases – pyoderma, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis; skin manifestations of syphilis,

skin tuberculosis, diaper rash, rosacea, extensive psoriatic rashes (plaques), anogenital itching; trophic ulcers of the leg associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract

intestinal tract, wounds at application sites; skin cancer, nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma; pregnancy and lactation period, children’s age (up to 2 years).

Use with caution in girls during puberty.

Side Effects

It is possible to develop secondary infectious skin lesions and atrophic changes in it (burning, itching, dry skin, steroid acne, folliculitis).

With long-term use – hypertrichosis, alopecia, especially in women, secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of the infectious process, development of opportunistic infections); skin atrophy, local hirsutism, telangiectasia, purpura, pigmentation disorder.

When applied to large surfaces, systemic manifestations are possible (gastritis, “steroidal” gastric ulcer, adrenal insufficiency, Itsenko-Cushing syndrome, “steroidal” diabetes mellitus, slowdown of reparative processes).

Interaction

Compatible with antimicrobial drugs.

Reduces the activity of antihypertensive, diuretic, antiarrhythmic drugs, potassium supplements.

Diuretic drugs (except potassium-sparing drugs) increase the risk of hypokalemia.

Overdose

Symptoms:

itching, burning of the skin at the site of application of the drug, hyperglycemia, glucosuria, Itsenko-Cushing syndrome.

Treatment:

symptomatic against the background of gradual drug withdrawal.

Storage conditions

At a temperature not exceeding 20 °C.

Keep out of the reach of children.

Shelf life

5 years

Manufacturer

Nizhpharm JSC, Russia