Sinaflan, 0.025% ointment 15 g

Glucocorticosteroid for external use; inhibits the release of inflammatory mediators. When exposed to the skin there is a prevention of marginal accumulation of neutrophils, which leads to a decrease in inflammatory exudate and cytokine production; inhibition of macrophage migration, reduction of infiltration and granulation processes. It has anti-inflammatory and antiallergic effect.
Pharmacokinetics:After absorption from the skin surface it is bound with plasma proteins and metabolized in liver with formation of inactive metabolites. It is excreted mainly by the kidneys.

Indications

Inflammatory and allergic skin diseases of non-microbial etiology, eczema, atopic dermatitis, simple chronic lichen (limited neurodermitis), skin itching, psoriasis and other chronic diseases accompanied by dry skin.

Active ingredient

Fluocinolone acetonide

Composition

100 g of ointment contains:

Active ingredient: fluocinolone acetonide – 0.025 g.

Auxiliary substances:

• propylene glycol – 4.975 g;
• vaseline – 80.0 g;
• ceresin – 10.0 g;
• lanolin – 5.0 g.

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How to take, the dosage

Outwardly

A small amount of the drug is applied to the skin 2-4 times a day with a tampon wetted with an antiseptic liquid and lightly rubbed in. If necessary an occlusive dressing may be applied and left on the affected surface for up to 3-4 days. It is not allowed to apply more than 2 g per day under the dressing.

Duration of treatment depends on the nature of the disease and efficiency of therapy, usually 5-10 days. In case of persistent course of the disease the treatment course may be prolonged up to 25 days (after consultation with the physician). In children it is recommended to use minimal effective doses, not more than 5 days.

Interaction

Compatible with antimicrobial drugs. Reduces the activity of hypotensive diuretic antiarrhythmic potassium drugs. Diuretic drugs (except potassium-saving drugs) increase the risk of hypokalemia.

Special Instructions

Use only short courses on small areas of the skin. It is recommended to wear loose clothing during treatment. The drug should not be applied to the face. Avoid getting the drug in the eyes. In the development of local infectious complications it is used in combination with antimicrobial drugs.