Rimantadine Avexima, tablets 50 mg 20 pcs

Prevention of Flu and Colds, ARI, Tick-borne Encephalitis, Flu

Prevention and early treatment of Influenza A in adults and children over 7 years old.

Indications

Prevention and early treatment of influenza A in adults and children over 7 years of age.

Special instructions

When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of developing hemorrhagic stroke.

If there is a history of epilepsy and ongoing anticonvulsant therapy while using rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg per day simultaneously with anticonvulsant therapy.

For influenza caused by virus B, rimantadine has an antitoxic effect. Prophylactic administration is effective during contacts with sick people, during the spread of infection in closed groups and at a high risk of developing the disease during an influenza epidemic. Viruses resistant to the drug may emerge.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Rimantadine

Composition

For one tablet:

active substances:

Rimantadine hydrochloride – 50 mg;

excipients:

lactose (milk sugar) – 60 mg,

potato starch – 37 mg,

calcium stearate – 1.5 mg,

talc – 1.5 mg.

Contraindications

Acute liver diseases,
acute and chronic kidney diseases,
thyrotoxicosis,
hypersensitivity to rimantadine,
pregnancy and lactation period,
children under 7 years old,
for lactase deficiency, lactose intolerance, lactose/isomaltose malabsorption syndrome (since the drug contains lactose).

Side Effects

From the digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence;

from the central nervous system: headache, dizziness, insomnia, neurological reactions, impaired concentration, drowsiness, anxiety, increased excitability, fatigue;

other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).

Interaction

Rimantadine reduces the effectiveness of antiepileptic drugs. Paracetamol and ascorbic acid reduce the maximum concentration of rimantadine in blood plasma by 11%. Cimetidine reduces the clearance of rimantadine by 18%.

Adsorbents, astringents and coating agents reduce the absorption of rimantadine.
Urine alkalizing agents (acetazolamide, sodium bicarbonate, etc.) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.

Overdose

Symptoms: agitation, hallucinations, arrhythmia.

Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions.

Rimantadine is partially eliminated by hemodialysis.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life

5 years

Manufacturer

Irbitsky Chemical Plant, Russia