Rhinonorm, spray 140 mcg/dose 20 ml

Pharmacological group: antikongestive – alpha-adrenomimetic.

ATX code: R01AA07

Pharmacological effect:

Xylometazoline is an alpha-adrenomimetic used for topical use in ENT practice.

When used topically, xylometazoline causes narrowing of arterioles, which results in decreased hyperemia and edema of nasopharyngeal mucous membranes and decreased secretion. A clear local action of the drug is revealed within a few minutes and remains for several hours (up to 6-8 hours), manifested in restoration of patency of nasal passages, sinus orifices and eustachian tubes. Restoration of nasopharyngeal air patency improves the patients’ well-being and reduces the risk of possible complications caused by mucous secretion congestion.

Pharmacokinetics:

When administered topically, xylometazoline is virtually not absorbed, so plasma concentrations are very low (not analytically detectable).

Indications

Active ingredient

Composition

1 dose of the drug contains the active ingredient: xylometazoline hydrochloride 0.14 mg; excipients: benzalkonium chloride (as 50% solution) 0.056 mg in terms of benzalkonium chloride 0.028 mg, citric acid monohydrate 0.07 mg, sodium citrate dihydrate 0.364 mg, glycerol 85% 3.36 mg, purified water 136.71 mg.

How to take, the dosage

Interaction

The concomitant use of tri- or tetracyclic antidepressants may increase the systemic effects of xylometazoline. Concomitant use of the drug with monoamine oxidase inhibitors (MAOIs) may increase the risk of hypertension.

Special Instructions

Patients with long QT interval syndrome taking xylometazoline may be at increased risk of serious ventricular arrhythmias.

Influence on driving, operating machinery:

No effect on driving ability or on operating machinery has been noted.

Synopsis

Contraindications

– hypersensitivity to xylometazoline or any of the drug’s excipients;

– arterial hypertension;

– tachycardia;

– severe atherosclerosis;

– glaucoma;

– hyperthyroidism;

– atrophic rhinitis;

– inflammatory diseases of the skin or mucous membrane of the vestibule;

– surgical interventions on the cerebral membranes (history);

– condition after transsphenoidal hypophysectomy;

– pregnancy;

p> – use of monoamine oxidase inhibitors (MAOIs) (including 14 days after their withdrawal), tricyclic or tetracyclic antidepressants;

– children under 6 years of age.

With caution:

Diabetes mellitus; severe cardiovascular disease (including coronary heart disease, angina pectoris); prostatic hyperplasia; pheochromocytoma; porphyria; breastfeeding period; hypersensitivity to adrenergic drugs accompanied by insomnia, dizziness, arrhythmias, tremors, increased blood pressure; patients with prolonged QT interval syndrome.

Side effects

Overdose

In rare cases of overdose, occurring mainly in children, the following symptoms may be observed: irregular pulse, increased blood pressure, in some cases – loss of consciousness. In case of overdose symptomatic treatment under supervision is indicated.

In serious cases, non-selective alpha-adrenoblockers may be used to reduce blood pressure, as well as intubation and artificial pulmonary ventilation. Vasoconstrictors are contraindicated.

In case of accidental ingestion of moderate to large amounts of the drug, activated charcoal (an absorbent) and sodium sulfate (a laxative) should be taken, and the stomach should be flushed.

Pregnancy use

Similarities