Rederm, ointment 30 g

Topical glucocorticosteroid + keratolytic agent

ATEx code: D07XC01

A combination drug for topical use, which action is due to its constituent components; the drug has anti-inflammatory, anti-allergic, antipruritic, keratolytic action. Betamethasone inhibits release of inflammatory mediators, prevents edge accumulation of neutrophils, reduces inflammatory exudate and cytokine production, reduces migration of macrophages which results in reduction of infiltration and granulation processes.

Owing to the presence of salicylic acid it softens the skin, eliminates stratum corneum and promotes deeper penetration of betamethasone.

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Indications

Psoriasis, Allergies, Urticaria, Itching, Eczema, Dermatitis, Dermatosis, Neurodermitis

Treatment of subacute and chronic dermatoses accompanied by hyperkeratosis and peeling:

– psoriasis;

– dyshydrotic dermatitis;

– eczema;

– neurodermatitis;

– red squamous lichen;

– ichthyosis and ichthyotic skin lesions;

– atopic dermatitis;

– diffuse neurodermitis;

– simple and allergic dermatitis;

– urticaria;

– erythema multiforme exudative;

– simple chronic lichen (limited neurodermitis);

– dermatoses that cannot be treated with other GCS (especially red warts);

– skin dyshidrosis.

Active ingredient

Betamethasone, Salicylic acid

Composition

100 g:

– betamethasone dipropionate in terms of betamethasone 0.05 g

– salicylic acid 3.0 g

excipients:

liquid paraffin (petroleum jelly),

Vaseline (vaseline white, paraffin white soft).

How to take, the dosage

Externally. It is applied to the affected areas at the rate of: 0.5 cm long column of Rederm ointment on an area of the skin measuring approximately 7 cm × 7 cm, rubbing lightly, in a thin layer 2 times a day.

A different frequency of application can be determined by the doctor, based on the severity of the disease. In mild cases, the ointment is usually enough to use once a day; more frequent use may be necessary for more severe lesions.

If necessary, occlusive dressings are applied and changed every 24 hours.

The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.

If there is no clinical improvement, the diagnosis needs to be clarified.

Interaction

Interaction of the drug with other medicines has not been revealed.

Special Instructions

Avoid contact of the drug with the eyes, do not apply to the skin near the eyes and mucous membranes. The drug is not intended for use in ophthalmology. During prolonged treatment, when applying the drug to large surfaces of the skin, when using occlusive dressings systemic absorption of glucocorticosteroids is possible.

Long-term use on the face is not recommended; rosacea-type dermatitis, perioral dermatitis, skin atrophy and acne are possible; avoid use in the anogenital area.

The ointment is most suitable for treating patients with dry and fragile skin.

If signs of skin hypersensitivity or irritation associated with use are noted, treatment should be discontinued and the patient should be appropriately treated.

When using the drug over a long period of time, it should be discontinued gradually.

Contraindications

Children under 2 years of age, lactation, hypersensitivity, open wounds, bacterial, viral and fungal skin diseases (pyoderma, syphilis, skin tuberculosis, varicella, herpes, actinomycosis, blastomycosis, sporotrichosis); postvaccination skin reactions, perioral dermatitis, rosacea, trophic ulcers with chronic venous insufficiency, skin tumors (skin cancer, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma).

With caution

Hepatic impairment, childhood (older than 2 years), long-term therapy, especially with occlusive dressings.

Side effects

• Burning, irritation, dryness, hypopigmentation, skin itching, folliculitis, hypertrichosis, dermatitis, acne-like rashes.
• When using occlusive dressings – skin maceration, stretch marks, skin atrophy, secondary infection, sweating.
• Long-term use – skin atrophy, local hirsutism, telangiectasia, purpura, hypopigmentation, hypertrichosis.
• .When applied to large surfaces – systemic side effects of glucocorticosteroids (growth retardation, Icenko-Cushing syndrome, increased intracranial pressure after treatment, hyperglycemia, glucosuria, hypokalemia, increased blood pressure) or salicylates (pallor, increased fatigue, sleepiness, hyperventilation against tachypnea, nausea, vomiting, hearing loss, confusion).

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Overdose

Acute overdose is unlikely; however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercorticism: hyperglycemia, glucosuria, reversible suppression of adrenal cortical function, manifestation of Cushing’s syndrome.

Treatment.

The appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

Pregnancy use

The safety of topical glucocorticosteroids in pregnant women has not been established. Administration of this group of drugs during pregnancy is justified only if the potential benefit to the mother exceeds the potential risk to the fetus. During pregnancy the drugs of this group should not be used in high doses or for a long time.

It is not known whether topical use of glucocorticosteroids can cause their appearance in the mother’s milk, so the question of stopping breastfeeding should be addressed.

Pediatric use

In children from 2 years of age the drug is prescribed only with strict indications and under medical supervision, because the development of systemic side effects associated with betamethasone is possible. Duration of treatment should be as short as possible. When using the drug on large surfaces and/or under an occlusive dressing, suppression of hypothalamic-pituitary-adrenal system function and development of hypercorticism symptoms may occur, reduction of growth hormone excretion and increased intracranial pressure may be observed.

Similarities

Diprosalik, Belosalik, Acriderm SC