Raso, 20 mg 30 pcs.

Pharmacodynamics

Mechanism of action

Rabeprazole belongs to the class of antisecretory drugs which are chemically substituted benzimidazoles. Rabeprazole inhibits the activity of the enzyme H+/K+ATPase (“proton pump”), thus blocking the final stage of hydrochloric acid synthesis. This effect is dose-dependent and leads to inhibition of both basal and stimulated hydrochloric acid secretion regardless of the irritant.

Rabeprazole has no anticholinergic properties.

Antisecretory activity

After oral administration of 20 mg rabeprazole the antisecretory effect occurs within one hour. Inhibition of basal and stimulated hydrochloric acid secretion 23 h after the first dose of rabeprazole is 62% and 82%, respectively, and continues until 48 h. This duration of pharmacokinetic action is much longer than that predicted by the half-life (T1/2), which is approximately 1 h.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Concomitant use with digoxin may increase (mild to moderate) plasma concentrations of digoxin.

Concomitant use with ketoconazole decreases its bioavailability.

Special Instructions

Contraindications

Side effects

Pregnancy use

Similarities