Protargol-LOR, tablets 200 mg 2 pcs

Pharmacotherapeutic group: Antiseptic agent

ATX code: D08AL

Pharmacological properties

Pharmacodynamics

Once in the body, silver proteinate dissociates to form silver ions, which have astringent, antiseptic and anti-inflammatory effects. Silver ions actively inhibit the reproduction of infectious agents by binding their DNA. The mechanism of action of protargol is based on the fact that silver ions precipitate proteins on damaged mucosa and form a protective film. This reduces sensitivity, narrows the blood vessels (this leads to a decrease in edema) and suppresses the inflammatory process. Silver ions also inhibit the reproduction of various bacteria. It is active against Gram-positive and Gram-negative bacteria: B.cereus, C.albicans, E.coli, P.aeruginosa. C.aureus, A.niger, S.abony, etc.

Pharmacokinetics

It is practically not absorbed when applied topically.

Indications

Symptomatic treatment of acute nasopharyngitis (runny nose), sinusitis.

Pharmacological effect

Pharmacotherapeutic group: Antiseptic

ATX code: D08AL

Pharmacological properties

Pharmacodynamics

When ingested, silver proteinate dissociates to form silver ions, which have an astringent, antiseptic and anti-inflammatory effect. Silver ions actively suppress the reproduction of infectious agents by binding their DNA. The mechanism of action of protargol is based on the fact that silver ions precipitate proteins on the damaged mucous membrane and form a protective film. At the same time, sensitivity decreases, blood vessels narrow (this leads to a decrease in swelling) and the inflammatory process is suppressed. Silver ions also inhibit the proliferation of various bacteria. Active against gram-positive and gram-negative bacteria: B.cereus, C.albicans, E.coli, P.aeruginosa. C.aureus, A.niger, S.abony, etc.

Pharmacokinetics

When applied topically, it is practically not absorbed.

Special instructions

Nasal discharge may turn gray or blue.

Read the instructions for use carefully before you start using the drug. Save the instructions, you may need them again. If you have any questions, consult your doctor.

The medicine you are being treated with is intended for you personally and should not be given to others as it may cause harm to them even if they have the same symptoms as you.

Effect of the drug on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Silver proteinate

Composition

Composition per tablet:

Active ingredient: silver proteinate (protargol) – 200.0 mg.

Excipient: hydroxypropyl methylcellulose – 10.0 mg.

Pregnancy

The use of the drug is contraindicated during pregnancy and breastfeeding

Contraindications

Hypersensitivity to the components of the drug, atrophic rhinitis, pregnancy, breastfeeding, children under 3 years of age (for this dosage).

Side Effects

– allergic reactions: skin itching, irritation of the mucous membrane, urticaria;

– burning sensation and numbness;

– dry mouth;

– redness of the eyes;

– anaphylactic shock;

– Quincke’s edema;

– atopic dermatitis.

Interaction

Pharmacodynamic, pharmacokinetic interaction: not studied. Pharmaceutical interaction: salts of zinc, copper, lead, silver, mercury, iron, aluminum form insoluble precipitates with a solution of silver proteinate; silver proteinate solution is inactivated by alkaloid salts and organic bases (epinephrine).

Overdose

Symptoms: with the recommended method of use, an overdose is unlikely. Possible increased side effects. If a large amount of the drug is accidentally swallowed, irritation of the gastrointestinal tract may occur. With prolonged uncontrolled use of the drug, it is theoretically possible for a very rare disease to appear – argyrosis (gray or bluish discoloration of the skin and mucous membranes). If the recommended dosage regimen is followed, the risk of argyrosis is unlikely.

Treatment: in case of severe irritation, burning, itching of the eyes, skin, mucous membranes, rinse with plenty of water for 15 minutes. Treatment is symptomatic.

Storage conditions

In original packaging at a temperature not exceeding 25°C.

Prepare the solution in a place protected from light at a temperature not exceeding 25°C. Keep out of reach of children

Shelf life

2 years.

Ready solution – 30 days.

Do not use after the expiration date stated on the package

Manufacturer

Pharmstandard-Leksredstva, Russia