Protamine sulfate suspension 10 mg/ml, 5 ml 10 pcs.
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Heparin antagonist, forms stable complexes with heparin, thus eliminating the ability of heparin to inhibit blood clotting.
Indications
BleedingHeparin overdose (hyperheparinemia, bleeding); before surgery in patients who take heparin for therapeutic purposes; after operations on the heart and blood vessels with extracorporeal circulation.
Active ingredient
Protamine sulfate
Composition
Active substance:
Protamine sulfate (in terms of dry substance) – 10 mg;
Associates:
0.05 M sulfuric acid solution – to pH 4.0-6.0
water for injection – up to 1 ml.
Interaction
Protamine sulfate is an antagonist of low molecular weight heparins.
Concomitant use with protamine sulfate may increase the intensity and duration of action of nondepolarizing myorelaxants.
Directions for use
Inject by IV fluids slowly or dropwise under control of blood clotting.
In case of heparin overdose, the drug is injected by jetting at a rate of 1 ml of 1% solution in 2 minutes. If necessary, the injections are repeated at intervals of 15-30 minutes, the total dose is usually 5 ml of 1% solution.
The maximum dose is 150 mg/h.
In case of bleeding, the daily dose is 5-8 mg/kg; IV drops are administered in 2 doses at 6-hour intervals.
Special Instructions
In overdose, it can reduce blood clotting, as it has anticoagulant activity.
Contraindications
Idiopathic or congenital hyperparinemia, marked arterial hypotension, thrombocytopenia, insufficiency of the adrenal cortex.
Side effects
Cardiovascular system: bradycardia, arterial hypotension.
Digestive system disorders: nausea, vomiting.
Allergic reactions: skin rash, itching.
Others: feeling of heat, hyperemia of the skin, feeling of shortness of breath (if injected too quickly).
Weight | 0.105 kg |
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Manufacturer | Ellara, Russia |
Medication form | suspension for injection |
Brand | Ellara |
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